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RNA sequencing reveals insight into tuberculosis infection
Using single-cell RNA sequencing, researchers have shown that interferon response is correlated with tuberculosis progression.
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Tuberculosis (TB)
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What is new in the world of imaging?
In this article, Drug Target Review’s Hannah Balfour discusses three of the latest developments in imaging for disease research and drug development.
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Adding to the arsenal: targeting human proteins for controlling M. tuberculosis growth
The National Institute of Health envisions a plan for managing tuberculosis in the 21st century. Included in this proposal is targeting host proteins as an add-on therapy to antibiotics. Infectious disease biologists are focusing on this strategy and it is a topic of active research. Recently, a multinational research team…
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Tuberculosis vaccine shown to protect older mice with type 2 diabetes
A study in older mice with type 2 diabetes revealed a tuberculosis vaccine elicited a strong immune response, making it a promising candidate for the condition.
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Novel tuberculosis transport protein could be target of new treatments
Cryogenic electron microscopy revealed that the vitamin B12 transporter on Mycobacterium tuberculosis acts like a non-selective sluice, transporting both the vitamin and antibiotics.
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Human tuberculosis blood signal replicated in mice
More research into tuberculosis is now possible with the development of an optimisied mouse model that exhibits the same blood immune response to Mycobacterium tuberculosis infection as humans.
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New treatment possible to tackle drug-resistant strains of TB
A new discovery could lead to the development of a drug for untreatable strains of TB, which can target uptake of the very amino acid that enables the bacteria to spread within the body.
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Tuberculosis mutation discovery could lead to better treatments
New gene mutation discovery could lead to more rapid and effective therapies for tuberculosis.
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Tuberculosis vaccine shows efficacy in pre-clinical trials
Australian researchers have demonstrated the success of a novel TB vaccine in mice, which could provide another treatment option for the disease.
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Key mechanism in tuberculosis survival discovered
A new study has revealed that M. tuberculosis uses a unique type of antacid which gives immune cells indigestion, enabling the bacteria to survive.
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Immune cell enzyme protects against tuberculosis
Using lung tissue from humans and mouse models, researchers have found that HO-1 controls inflammation and protects against tuberculosis...
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Non-antibiotic drug developed to treat TB
Scientists at The University of Manchester have developed the first non-antibiotic drug to successfully treat tuberculosis in animals...
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Gene signature holds promise for early detection of active TB
A gene signature in the bloodstream could reveal whether someone is going to develop active tuberculosis (TB) disease months before symptoms begin.
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Link between TB and Parkinson’s disease identified
The mechanism our immune cells use to clear bacterial infections like tuberculosis might also be implicated in Parkinson's disease...
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Novel metabolic mechanism holds potential as tuberculosis drug target
Researchers from the Cornell University College of Veterinary Medicine, New York, have discovered a key metabolic mechanism in Mycobacterium tuberculosis (Mtb) bacteria, which presents as a novel drug target for potentially treating tuberculosis.