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Tuberculosis (TB)

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RNA sequencing reveals insight into tuberculosis infection

17 February 2021 | By Victoria Rees (Drug Target Review)

Using single-cell RNA sequencing, researchers have shown that interferon response is correlated with tuberculosis progression.

Close up of a light microscopy being used by a researcher - image shows just the metal lens and table with slide on

article

What is new in the world of imaging?

21 January 2021 | By Hannah Balfour (Drug Target Review)

In this article, Drug Target Review’s Hannah Balfour discusses three of the latest developments in imaging for disease research and drug development.

article

Adding to the arsenal: targeting human proteins for controlling M. tuberculosis growth

11 September 2020 | By Navodita Jain (Syngene International)

The National Institute of Health envisions a plan for managing tuberculosis in the 21st century. Included in this proposal is targeting host proteins as an add-on therapy to antibiotics. Infectious disease biologists are focusing on this strategy and it is a topic of active research. Recently, a multinational research team…

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Tuberculosis vaccine shown to protect older mice with type 2 diabetes

11 August 2020 | By Victoria Rees (Drug Target Review)

A study in older mice with type 2 diabetes revealed a tuberculosis vaccine elicited a strong immune response, making it a promising candidate for the condition.

tuberculosis bacteria - long thin gerkin-like structures

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Novel tuberculosis transport protein could be target of new treatments

1 April 2020 | By Hannah Balfour (Drug Target Review)

Cryogenic electron microscopy revealed that the vitamin B12 transporter on Mycobacterium tuberculosis acts like a non-selective sluice, transporting both the vitamin and antibiotics.

Human tuberculosis blood signal replicated in mice

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Human tuberculosis blood signal replicated in mice

24 March 2020 | By Rachael Harper (Drug Target Review)

More research into tuberculosis is now possible with the development of an optimisied mouse model that exhibits the same blood immune response to Mycobacterium tuberculosis infection as humans.

news

New treatment possible to tackle drug-resistant strains of TB

5 December 2019 | By Rachael Harper (Drug Target Review)

A new discovery could lead to the development of a drug for untreatable strains of TB, which can target uptake of the very amino acid that enables the bacteria to spread within the body.

news

Tuberculosis mutation discovery could lead to better treatments

6 September 2019 | By Rachael Harper (Drug Target Review)

New gene mutation discovery could lead to more rapid and effective therapies for tuberculosis.

news

Tuberculosis vaccine shows efficacy in pre-clinical trials

2 September 2019 | By Victoria Rees (Drug Target Review)

Australian researchers have demonstrated the success of a novel TB vaccine in mice, which could provide another treatment option for the disease.

news

Key mechanism in tuberculosis survival discovered

19 August 2019 | By Victoria Rees (Drug Target Review)

A new study has revealed that M. tuberculosis uses a unique type of antacid which gives immune cells indigestion, enabling the bacteria to survive.

news

Immune cell enzyme protects against tuberculosis

14 November 2018 | By Drug Target Review

Using lung tissue from humans and mouse models, researchers have found that HO-1 controls inflammation and protects against tuberculosis...

news

Non-antibiotic drug developed to treat TB

11 September 2018 | By Drug Target Review

Scientists at The University of Manchester have developed the first non-antibiotic drug to successfully treat tuberculosis in animals...

news

Gene signature holds promise for early detection of active TB

20 June 2018 | By Drug Target Review

A gene signature in the bloodstream could reveal whether someone is going to develop active tuberculosis (TB) disease months before symptoms begin.

news

Link between TB and Parkinson’s disease identified

23 May 2018 | By Dr Zara Kassam (Drug Target Review)

The mechanism our immune cells use to clear bacterial infections like tuberculosis might also be implicated in Parkinson's disease...

news

Novel metabolic mechanism holds potential as tuberculosis drug target

28 June 2017 | By Niamh Marriott (Drug Target Review)

Researchers from the Cornell University College of Veterinary Medicine, New York, have discovered a key metabolic mechanism in Mycobacterium tuberculosis (Mtb) bacteria, which presents as a novel drug target for potentially treating tuberculosis.

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Tuberculosis (TB)