news
Non-opioid based target identified to potentially treat chronic pain
Researchers have discovered that blocking TRPC5 activity treated chronic pain in mouse models of various conditions.
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sickle cell disease
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Organ-on-a-chip model developed to aid sickle cell disease treatment
Researchers have developed a novel organ-on-a-chip model of sickle cell disease to improve personalised medicine.
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Genomic assays: on the brink of revolutionising human healthcare
Detailed knowledge of the human genome can provide us with extensive information about the causes of disease and how patients will respond to treatments. In this article, Pushpanathan Muthuirulan explores the concept of genetic testing and the potential for pharmacogenomic testing to transform healthcare.
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CRISPR: kick-starting the revolution in drug discovery
Gene editing using the CRISPR system has been established as the most powerful tool in the search for new drugs and is now being exploited for therapeutic purposes. Here, Pushpanathan Muthuirulan discusses the promises and wider opportunities of using CRISPR technology to open up the possibility of large-scale screening of…
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Targeting a blood stem cell subset shows lasting gene editing
Scientists report how editing a portion of stem cells with CRISPR-Cas9 is sufficient for long-term reactivation of therapeutic haemoglobin.
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Novel nanoparticles improve CRISPR gene editing
A study has used new synthetic lipids to deliver CRISPR gene editing tools into cells with up to 90 percent efficiency.
