This article delves into research at the University of California Los Angeles, US, where stem-cell derived brain organoids that can mimic electrical activity have been developed.
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Two drugs, Nefiracetam and PHA 543613, were able to return neuronal signalling to near normal in organoids derived from patients with the autism spectrum disorder, Rett syndrome.
Researchers have found that a compound named JQ1, an experimental cancer drug, extends the life of mice with Rett syndrome.
Researchers describe how a new drug is able to reduce the symptoms and activate the dormant neurons characteristic of Rett Syndrome...
Reactivation of the inactive X chromosome could lead to an increased expression of the healthy protein underlying the neurodevelopmental disorder...