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Parkinson's disease

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Alterity’s ATH434 improves Parkinson’s-related gastrointestinal dysfunction

4 November 2021 | By Anna Begley (Drug Target Review)

ATH434 reversed some of the gastrointestinal damage to the enteric nervous system associated with Parkinson's disease in a pre-clinical study.

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Gene therapy bolsters Parkinson’s drug benefits in pre-clinical study

3 November 2021 | By Anna Begley (Drug Target Review)

The gene therapy restored the ability of neurons to convert levodopa to dopamine and may help develop therapies to slow disease progression.

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$9 million grant awarded to uncover whether Parkinson’s starts in the nose

29 October 2021 | By Anna Begley (Drug Target Review)

A new grant will allow an international team to determine if scent-processing nerves in the nose play a role in the development of Parkinson's and could aid in the development of novel therapeutics.

Care worker holding hand of Parkinson's patient

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Mission Therapeutics receives $500k grant for Parkinson’s research

14 October 2021 | By Anna Begley (Drug Target Review)

Mission Therapeutics was granted $500,000 from the The Michael J Fox Foundation for Parkinson’s Research for DUB inhibitor testing.

article

Determining the structure of nanobodies using nuclear magnetic resonance spectroscopy

23 September 2021 | By Professor Gennaro Esposito (NYU Abu Dhabi)

Scientists at the New York University (NYU) Abu Dhabi have used nuclear magnetic resonance (NMR) techniques to determine the structure of a specific nanobody, Nb23. Drug Target Review’s Victoria Rees spoke with lead researcher Professor Gennaro Esposito to find out how their findings could lead to a better understanding of…

Person holding hand of Parkinson's disease patient

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Nasal drugs show promise for slowing Parkinson’s disease

22 September 2021 | By Anna Begley (Drug Target Review)

Two different peptides were found to slow the spread of alpha-synuclein, potentially becoming the first drugs to slow the progression of Parkinson’s disease.

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Multi-omics approach identifies genes associated with alcohol use disorder

23 August 2021 | By Anna Begley (Drug Target Review)

First-of-its-kind study uses a multi-omics approach to provide a list of causal candidate genes associated with alcohol use disorder (AUD).

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Mechanisms behind synapse degeneration in Alzheimer’s unveiled

20 August 2021 | By Anna Begley (Drug Target Review)

Researchers have uncovered a signalling pathway associated with glutamatergic synapse degeneration in the brains of mice with Alzheimer’s.

news

New study discovers how Parkinson’s-linked protein attacks mitochondria

19 August 2021 | By Anna Begley (Drug Target Review)

Researchers have used fruit fly larvae to explore how alpha-synuclein impacts the mitochondria, advancing the study of Parkinson’s disease.

news

TREM2 regulation to prevent neurodegeneration is possible, study shows

13 August 2021 | By Anna Begley (Drug Target Review)

Scientists used a synthetic thyroid hormone in mice to regulate the TREM2 gene implicated in diseases such as Alzheimer’s and Parkinson’s.

news

Mitochondria repair in mice may provide answers on Parkinson’s disease

4 August 2021 | By Anna Begley (Drug Target Review)

Researchers used an experimental small molecule that helped restore the removal of damaged mitochondria from brain cells in a mouse model of Parkinson's.

news

Nanosized molecules inhibit formation of plaques related to Alzheimer’s

5 July 2021 | By Victoria Rees (Drug Target Review)

In brain tissues, researchers have shown that two different nanosized polyoxoniobate molecules can inhibit the assembly of amyloid plaques.

news

Study provides clues to cause and possible treatment of Parkinson’s

14 June 2021 | By Victoria Rees (Drug Target Review)

Researchers have shown that the leakage of mitochondrial double-stranded DNA into the cell can contribute to Parkinson's disease.

Alpha-synuclein imaged by Raman spectroscopy

news

Raman spectroscopy platform developed to characterise IDPs

29 April 2021 | By Victoria Rees (Drug Target Review)

Optical tweezers-coupled Raman spectroscopy has been used to reveal the structure of alpha-synuclein, an IDP linked to Parkinson's disease.

news

Behavioural screen in C. elegans reveals Parkinson’s drug candidates

24 February 2021 | By Victoria Rees (Drug Target Review)

Researchers have developed a workflow to study the behaviour of C. elegans in a high-throughput screen to identify Parkinson's disease drugs.

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Parkinson's disease