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Parkinson's

sagittal (side through view) magnetic resonance image of the brain with skull and supporting structures in purple and brain and brainstem in red and orange

Refreshing how we approach neuroscience with a novel screening technology

9 April 2020 | By Hannah Balfour (Drug Target Review)

Drug Target Review discusses how NETSseq, a novel profiling technology, is bringing new insights to neurodegenerative and psychiatric diseases.

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Novel ligands developed with high affinity for Alzheimer’s receptors

7 April 2020 | By Victoria Rees (Drug Target Review)

A group of researchers has synthesised a new class of ligands which bind with high affinity to imidazoline I2 receptors, a drug target for Alzheimer's disease.

Parkinson's Disease dopamine neuron with alpha-synuclein Lewy Body inside

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BT13 molecule shows promise for halting Parkinson’s

18 February 2020 | By Nikki Withers (Drug Target Review)

A molecule has been shown to increase dopamine levels in the brains of mice, offering hope for stopping the progression of Parkinson’s.

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Researchers discover α-synuclein clue to treating Parkinson’s

17 January 2020 | By Victoria Rees (Drug Target Review)

A study has shown that fruit fly larvae lacking a certain region of the α-synuclein protein did not exhibit Parkinson’s symptoms, indicating a potential target.

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Screening platform reveals compounds that protect neuronal mitochondria

13 January 2020 | By Victoria Rees (Drug Target Review)

Researchers have developed a screening system and identified a set of compounds that protect neuronal mitochondria in mice.

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Exosomes used by researchers as form of novel gene therapy

17 December 2019 | By Victoria Rees (Drug Target Review)

A study has demonstrated that exosomes can be used as nanocarriers for therapeutic contents, as a new type of gene therapy.

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Rhomboid protease role observed using dynamic imaging

28 October 2019 | By Rachael Harper (Drug Target Review)

Researchers have been able to watch rhomboid proteases in a native lipid environment which may be useful for the development of Parkinson's and malaria medication.

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Neurodegeneration enzyme identified in mouse models

25 June 2019 | By Drug Target Review

A new study has found an enzyme in the brains of mice models which induces Parkinson’s, suggesting future drug target.

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Molecule which targets Parkinson’s protein identified

6 June 2019 | By Victoria Rees (Drug Target Review)

A new study has identified a molecule which targets a protein linked with Parkinson’s.

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Compounds in coffee may fight Parkinson’s

11 December 2018 | By Drug Target Review

Caffeine plus another compound in coffee beans' waxy coating may protect against brain degeneration...

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Ageing hallmark in neurons discovered by biologists

27 November 2018 | By Drug Target Review

Oxidative stress occuring in neurons produces unusual piles of short snippets of RNA and could be a marker of neurodegenerative diseases...

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Inhibiting USP13 destroys toxic clumps seen in Parkinson’s disease

14 November 2018 | By Drug Target Review

A team of neurologists have found that one reason Lewy bodies develop is that a molecule, USP13, has removed all the "tags" placed on alpha-synuclein that mark the protein for destruction...

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Better drug delivery through the blood-brain barrier

19 October 2018 | By Iqra Farooq (Drug Target Review)

Drug delivery through the blood-brain barrier has shown to be difficult to overcome, but researchers may have discovered a method to overcome this issue...

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Laser-capture RNA seq technique connects Parkinson’s and psychiatric diseases

21 September 2018 | By Drug Target Review

A comprehensive study reveals an expanding universe of 'darkest of the dark matter' RNAs in dopamine-producing cells in our brains...

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The molecular link between ageing and neurodegeneration

28 August 2018 | By Drug Target Review

Researchers have described the discovery of a molecular link between ageing and a major genetic cause of both ALS and FTD...

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Parkinson's