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Neuroblastoma

news

New class of CAR T cells combat previously “untargetable” cancer drivers

4 November 2021 | By Anna Begley (Drug Target Review)

The peptide-centric chimeric antigen receptors killed neuroblastoma cells in mice and could potentially expand the pool of immunotherapeutic targets.

article

Recognition of phosphohistidine-containing peptides by antibodies

16 July 2021 | By Dr Rajasree Kalagiri (Salk Institute), Professor Tony Hunter (Salk Institute)

In this article, Dr Rajasree Kalagiri explains research into the use of monoclonal antibodies for the differential recognition of phosphohistidine-containing peptides.

news

Tumour cell vaccine strategy developed for neuroblastoma and melanoma

1 April 2021 | By Victoria Rees (Drug Target Review)

A combination of checkpoint and small molecule inhibitors showed success at targeting Myc oncogenes in mouse neuroblastoma and melanoma models.

news

New drug target identified to potentially fight neuroblastoma

29 March 2021 | By Victoria Rees (Drug Target Review)

Researchers have revealed that the protein ALYREF promotes the effects of the neuroblastoma gene, MYCN, making it a target.

news

Single cell analysis reveals sympathoblasts as target to treat neuroblastoma

8 February 2021 | By Victoria Rees (Drug Target Review)

Researchers have discovered that all childhood neuroblastomas come from sympathoblasts, making them a drug target to treat the condition.

Chimeric Antigen Receptor T cells in red attacking cancer cells in blue

news

Could synNotch CAR T cells be the answer to fighting solid tumours?

22 January 2021 | By Hannah Balfour (Drug Target Review)

Researchers have developed a novel CAR T-cell therapy for neuroblastoma which uses gating to limit toxicity and T-cell exhaustion.

news

Lead drug candidate identified as potential neuroblastoma treatment

7 October 2020 | By Victoria Rees (Drug Target Review)

Using hit-to-lead processes, researchers have discovered that KSP inhibitors prevent tumour growth and prolong survival in mice with neuroblastoma.

Neuroblastoma cells: nuclei are stained in red, microfilaments are in green and blue.

news

Novel targeted treatment shows efficacy in treating high-risk solid tumours

25 August 2020 | By Hannah Balfour (Drug Target Review)

The prodrug developed by researchers caused long-term remission in all murine models of high-risk or drug-resistant cancers with fewer side-effects than a comparable drug.

dendritic cell presenting antigens to T cells with cut away of the T cell receptor and antigen on MHC binding

news

High-throughput protocol for producing tetramer assay probes used to investigate COVID-19

21 April 2020 | By Hannah Balfour (Drug Target Review)

The developers of a novel method to create immunological assay probes for screening T cells has leveraged their new protocol against COVID-19.

news

Researchers discover new neuroblastoma drug target

31 July 2019 | By Victoria Rees (Drug Target Review)

A study has discovered that reducing expression of a key gene in neuroblastoma tumourigenesis is an important drug target for the condition.

news

MMP20 gene variants linked to high-risk childhood cancers

26 September 2017 | By Dr Zara Kassam (Drug Target Review)

Paediatric researchers have identified common gene variants that raise the risk of an aggressive forms of childhood cancer...

news

Tumours detected with sugar molecules

15 August 2017 | By Dr Zara Kassam (Drug Target Review)

Scientists have synthesised a complex sugar structure that specifically binds to the tumour protein Galectin-1...

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Neuroblastoma