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multiple myeloma

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Novel inhibitor blocks myeloma cancer cell growth in mouse model

18 May 2021 | By Victoria Rees (Drug Target Review)

Having identified the histone demethylase KDM5A as a multiple myeloma target, researchers developed a KDM5 inhibitor to treat the cancer.

article

Preventing stem cells from transforming into pre-leukaemia stem cells

1 February 2021 | By Victoria Rees (Drug Target Review)

Researchers have discovered that two enzymes called APOBEC3C and ADAR1 work together to fuel the transition from pre-cancer stem cells to cancer stem cells in leukaemia.

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Novel IRF4 inhibitor shows promise as myeloma treatment in mice

21 January 2021 | By Victoria Rees (Drug Target Review)

An antisense oligonucleotide has been developed by researchers to inhibit IRF4 as a potential strategy to treat multiple myeloma.

news

New α-radioimmunotherapy shows promise as multiple myeloma treatment in mice

7 August 2020 | By Victoria Rees (Drug Target Review)

An α-radioimmunotherapy called 212Pb-anti-CD38 was effective at preventing tumour growth and increasing survival in multiple myeloma tumour-bearing mice, a study has shown.

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New molecule shows efficacy at fighting multiple myeloma in mice

30 March 2020 | By Victoria Rees (Drug Target Review)

A new compound, called FL118, was effective at combatting multiple myeloma in advanced stages of the condition in patient samples as well as mice, say researchers.

CAR T cell receptor binding to cell surface protein

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CD229 CAR T-cell therapy treated tumours had lasting response mice

10 February 2020 | By Hannah Balfour (Drug Target Review)

Researchers have created a CAR T-cell therapy which targets the CD229 molecule expressed on all multiple myeloma cells and killed human tumour cells in mice.

news

Urine tests are important in diagnosing myeloma

16 July 2018 | By Drug Target Review

It may be better to examine the urine and the blood of patients suspected of tumours of the plasma cells...

news

Scientists give tumour-fighting cells a boost in battling bone marrow cancer

2 June 2017 | By Niamh Marriott (Drug Target Review)

Researchers uncovered a new way to enhance the function of a specific type of immune cell that destroys tumours in multiple myeloma...

news

Takeda to enrol 5000 patients in giant multiple myeloma trial

1 September 2016 | By Niamh Louise Marriott, Digital Content Producer

Takeda’s global non-interventional, observational multiple myeloma study is now enrolling patients, aiming to have 5,000 patients over three years with a goal of following each patient for a minimum of five years in an effort to track patterns in disease presentation, patient characteristics, treatment and outcomes, thereby enhancing the understanding…

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multiple myeloma