article Development of a physiologically relevant lung model for understanding SARS-CoV-2 infection 27 November 2020 | By Professor Lyle Armstrong (Newcastle University and Newcells Biotech) COVID-19 is known to infect the lungs; however, the dynamics of viral infection and replication are poorly understood. Alongside the Liverpool School of Tropical Medicine, Professor Lyle Armstrong and colleagues have been working to develop a human lung epithelium model of SARS-CoV-2 infection and replication. In this article, he describes…
news Targeting host proteins could lead to pan-coronavirus antivirals 16 October 2020 | By Hannah Balfour (Drug Target Review) Researchers suggest that targeting host proteins with drugs, rather than directly targeting enzymes or proteins on SARS-CoV-2 and related coronaviruses, could improve outcomes.
news Human enzymes could be driving COVID-19 evolution, suggest researchers 21 May 2020 | By Hannah Balfour (Drug Target Review) Post-infection genome editing could be the cause of mutations in the SARS-CoV-2 virus responsible for the COVID-19 pandemic, driving its evolution.
news Remdesivir most promising COVID-19 drug, say researchers 27 March 2020 | By Hannah Balfour (Drug Target Review) A review of potential COVID-19 therapeutics revealed that the most effective are likely to be those directly targeting SARS-CoV-2, such as remdesivir and tilarone.
news Coronavirus update: recent developments in vaccine research 27 February 2020 | By Hannah Balfour (Drug Target Review) Drug Target Review’s round-up of the latest developments in 2019 novel coronavirus (COVID-19 or SARS-CoV-2) therapeutics and vaccines.
news Electron microscopy details infection mechanisms of coronaviruses 29 February 2016 | By Victoria White High-resolution cryo-electron microscopy and supercomputing have now made it possible to analyse in detail the infection mechanisms of coronaviruses...
news MERS treatment demonstrates promising results in mice 18 February 2016 | By Victoria White The treatment - an antibody that blocks the MERS virus - was produced by cows that had been genetically modified to mimic certain aspects of the human immune system...
news FDA clears first-in-human clinical study for MERS vaccine 19 November 2015 | By Victoria White GeneOne Life Science and Inovio are co-developing the vaccine and plan to initiate the first human trial of a MERS vaccine before the end of the year...
news GeneOne Life Science and WRAIR to develop MERS vaccine 11 November 2015 | By Victoria White Earlier this year, GLS-5300 induced 100% protection from a live MERS virus challenge in a preclinical animal study...
news BBI acquires exclusive global licence for MERS and SARS vaccines 21 October 2015 | By Victoria White BBI has acquired an exclusive global license for the clinical development and commercialisation of the vaccines...
news Investigational New Drug Application filed for MERS vaccine 19 October 2015 | By Victoria White Earlier this year, Inovio’s MERS vaccine induced 100% protection from a live virus challenge in a preclinical study...
news MERS-CoV vaccine successfully tested in monkeys and camels 20 August 2015 | By Victoria White Scientists have reported that an experimental vaccine given six weeks before exposure to MERS-CoV fully protects rhesus macaques from disease...
news Experimental MERS vaccine shows promise in animal studies 29 July 2015 | By Victoria White A two-step regimen of experimental vaccines against Middle East respiratory syndrome (MERS) prompted immune responses in mice and rhesus macaques...
news Regeneron’s Veloci-technologies used to develop human antibodies in the fight against MERS 30 June 2015 | By Victoria White A study has demonstrated that Veloci-technologies enabled rapid identification and validation of potential candidates that could be developed to treat MERS...
news Purdue researchers successfully target ‘Achilles’ heel’ of MERS virus 23 June 2015 | By Victoria White Researchers studying MERS have found molecules that shut down the activity of an essential enzyme in the virus that could lead to a treatment for the virus...
