news Inhibiting sortilin could make pancreatic cancer therapies more effective 21 August 2020 | By Hannah Balfour (Drug Target Review) A study has shown that inhibiting sortilin, a neuroprotein known to have increased expression in cancers, reduces pancreatic cancer invasiveness in vitro.
news Proteomic map of human lung adenocarcinoma revealed 13 July 2020 | By Hannah Balfour (Drug Target Review) The proteomic map based on data from 103 patients reveals novel prognostic biomarkers and potential drug targets for lung adenocarcinoma.
news Novel antibody slows cancer growth and metastasis in mice 27 April 2020 | By Hannah Balfour (Drug Target Review) The antibody targets a cell receptor in blood vessels and slowed breast and lung cancer growth as well as metastasis in murine models.
news IL-27 could work as potential immunotherapy against cancers 8 April 2020 | By Victoria Rees (Drug Target Review) Researchers have created a new kind of immunotherapy using the interleukin-27 (IL-27) cytokine to effectively combat tumours in vitro and in vivo.
news Receptors enabling COVID-19 infection found on cilia progenitor cells, study shows 8 April 2020 | By Victoria Rees (Drug Target Review) Sequencing almost 60,000 cells, researchers have found that certain cilia progenitor cells have gene transcripts for ACE2 and co-factor TMPRSS2, enabling COVID-19 infection.
news Researchers identify target to improve dendritic cell ability to fight tumours 31 March 2020 | By Victoria Rees (Drug Target Review) A new study has shown that the role of T cell-suppressing dendritic cells can be reversed in mice, indicating that immunotherapies could be improved with this method.
news High-throughput screening reveals new compound to maintain lung health 21 February 2020 | By Victoria Rees (Drug Target Review) Researchers have screened 20,000 molecules to discover a potent compound with low toxicity that restores the balance of healthy stem cells in the lungs of mice.
news WDR74 protein identified as lung cancer and melanoma therapeutic target 17 February 2020 | By Victoria Rees (Drug Target Review) Researchers have revealed that the WDR74 protein plays a key role in lung cancer and melanoma, including metastasis, indicating it may be a potential drug target.
news Genes associated with heavy alcohol use may also impact compulsive behaviour and addiction 15 January 2020 | By Hannah Balfour (Drug Target Review) A study suggests there may be common genetic pathways between alcohol use disorder and other addictions, so GWAS identification of affected genes could provide the targets for new therapies.
news Cancer cells killed in mice using copper-based nanomaterials 13 January 2020 | By Rachael Harper (Drug Target Review) Copper oxide nanoparticles have successfully killed tumour cells in mice and when combined with immunotherapy, could work as a vaccine for cancer.
news Blocking kinase could provide treatment for prostate cancer 29 August 2019 | By Victoria Rees (Drug Target Review) Researchers have found that inhibiting a kinase in mice leads to the death of prostate cancer cells, providing a potential therapeutic target.
news Study reveals antioxidant role in spread of lung cancer 1 July 2019 | By Victoria Rees (Drug Target Review) Researchers have discovered that lung cancer cells metastasise using antioxidants, informing potential future therapies.
news Heme-sequestering peptides may help stall lung cancer 25 April 2019 | By Drug Target Review Scientists have demonstrated that the growth rate of the majority of lung cancer cells relates directly to the availability of a crucial oxygen-metabolising molecule.
news Single-cell sequencing reveals landscape of immune cell subtypes in lung cancer tumours 10 April 2019 | By Drug Target Review Researchers have used single-cell sequencing to map the landscape of myeloid cells in tumours from patients with lung cancer...
news MicroRNA regulates drug tolerance in subset of lung cancers 9 April 2019 | By Drug Target Review Newly identified pathway offers promising targets for preventing tumour relapse...
