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Ischemic stroke

Brain scan with red areas, indicating stroke

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Neurolysin shown to be potential drug target for ischemic stroke

13 October 2021 | By Anna Begley (Drug Target Review)

Researchers are identifying molecules that interact with neurolysin, a peptidase that helps protect the brain against stroke.

Doctor standing behind DNA molecules, representing gene therapy

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Gene therapy method could restore visual function after stroke

4 October 2021 | By Anna Begley (Drug Target Review)

Scientists have revealed a way to use gene therapy to turn glial brain cells into neurons, restoring vision and potentially restoring motor function.

news

IAIPs shown to reduce ischemic stroke damage in pre-clinical study

2 September 2021 | By Anna Begley (Drug Target Review)

Inter-alpha inhibitor proteins (IAIP) demonstrated efficiency in reducing damage from an ischemic stroke, reveals pre-clinical study.

news

New mRNA delivery system effectively protects neurons in rats from ischemia

9 April 2021 | By Victoria Rees (Drug Target Review)

Researchers have shown that an mRNA delivery system can be used to produce the BDNF protein in rats to protect neurons from ischemia.

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Team modifies therapeutic molecule to improve stroke treatment

19 February 2021 | By Victoria Rees (Drug Target Review)

Researchers have shown that adding a polymer to glutamate-oxaloacetate transaminase means the molecule can treat stroke for up to six days in rats.

man with hand over heart with cutaway of a blood vessel with a blood clot

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Novel antiplatelet drug is effective at treating heart attacks in mice, say researchers

16 July 2020 | By Hannah Balfour (Drug Target Review)

The novel nanoparticle delivered Mp6 peptide was able to inhibit thrombosis and reduce inflammation without increasing the risk of bleeding in mice after heart attacks.

Even after a blocked vessel has been opened, immune cells in the brain (green) continue to attack synapses (red) and neurons (magenta) in the memory center of the brain, the hippocampus, for at least 30 days after stroke.

news

Novel complement inhibitor improves ischemic stroke recovery in mice, say researchers

3 June 2020 | By Hannah Balfour (Drug Target Review)

Administering a novel complement protein blocker (B4Crry) alongside reperfusion therapy improved cognitive and motor recovery in a model of ischemic stroke.

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B cells may travel to remote areas of the brain to improve stroke recovery

19 February 2020 | By Victoria Rees (Drug Target Review)

Research has found that after stroke in mice, B cells migrate to far regions of the brain that control motor functions, indicating their role in recovery.

x-ray of human head with a red spot indicating a region of stroke

news

Retinoid X receptor could be targeted to improve recovery from stroke

6 February 2020 | By Hannah Balfour (Drug Target Review)

Scientists conducted a pre-clinical trial in mice and showed that activating the retinoid X receptor (RXR) enhances the activity of phagocytic immune cells and aids recovery from stroke.

news

PSD-95 molecule reveal potential treatment for stroke patients

3 October 2018 | By Drug Target Review

A novel hybrid approach has revealed a 3D structure of a protein fragment that could serve as a drug target in treating stroke patients...

news

New study proves e-ASPECTS could predict benefit of mechanical thrombectomy

22 June 2017 | By Sarah Wills (Drug Target Review)

A new study shows e-ASPECTS correlates with and is a predictor of outcome after mechanical thrombectomy. With mechanical thrombectomy gaining ground as a possible treatment for patients suffering from acute ischemic stroke, it is even more important to select those patients who can derive the most benefit.

news

Benzodiazepines increase stroke risk in Alzheimer’s patients

16 January 2017 | By Niamh Marriott (Drug Target Review)

The use of benzodiazepines and benzodiazepine-like drugs was associated with a 20% increased risk of stroke among persons with Alzheimer’s disease, shows a recent study from the University of Eastern Finland.

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Ischemic stroke