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DTR’s news round-up 2019: the stories that defined the year
Drug Target Review lists its 10 most popular news stories from 2019, summarising the drug targets that you wanted to read about.
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Diabetes
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New insights into major disease pathways made with protein discovery
A new chemical tool has been used to identify hundreds of modified proteins which allows new insights to major diseases.
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Activating bone stem cells has potential therapeutic applications
A study has demonstrated that activating bone periosteal stem cells leads to increased bone healing in mice, presenting a potential therapeutic strategy.
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Common signalling pathway across cancer and diabetes discovered by researchers
Researchers have found that the TRAP-alpha insulin biosynthesis pathway is essential in both cancer and diabetes, with a common primordial ancestor discovered in C. elegans.
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Dysfunctional B cells found to contribute to age-related metabolic disease
A study has shown that a group of cells called adipose B cells can become dysfunctional with age, causing metabolic conditions such as diabetes, which has provided a drug target.
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Optogenetics used to control diabetes without medication
Scientists in the US have successfully controlled glucose levels in diabetic mouse models without the need for medication.
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Key mechanism behind insulin release discovered by researchers
Researchers have identified a specific receptor that is critical for the release of insulin and provides a target for diabetes and obesity.
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Largest genome sequencing project launched in UK
The UK Biobank, the world’s largest genetics project, will sequence 500,000 genetic samples, which will be available to researchers everywhere.
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Pancreas-on-a-chip technology to aid in diabetes research
Scientists combine organ-on-a-chip and stem-cell technologies to make a powerful tool for diabetes research.
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Fruit fly model for studying uric acid diseases developed
Researchers have created a fruit fly model to investigate uric acid-related diseases such as diabetes to aid in drug development.
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Study discovers key process in the cause of cell aging
Researchers have identified a key process behind senescence, or why cells age, which could be used to improve treatments for cancer.
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Five latest developments for models
The use of models is a key feature of preclinical studies and in recent months there have been several new advancements in this area. This article investigates five of the latest developments.
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Researchers reverse prediabetes in mice through enzyme deactivation
A study has shown that deactivating an enzyme linked to ceramides caused obese mice to improve their metabolic health, indicating a drug target.
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Crystals mapped to advance treatments for stroke, diabetes and dementia
Researchers haved mapped the crystal structure of a protein to find out how a drug latches onto it.
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Eye protein could protect against diabetic eye disease
New research has identified a potential treatment against diabetic eye disease from the RBP3 protein, found in the retina.
