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Measuring microRNAs in blood may indicate dementia risk
Researchers identified three microRNAs whose levels were associated with mental performance in cells, mice and humans.
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Dementia
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An integrated vaccination approach to neurodegeneration
Guided by precise biomarker tests, therapeutic vaccines targeting the pathology of neurodegenerative disease could provide solutions to the impending global crisis in dementia. As Dr Andrea Pfeifer, Co-Founder, Chief Executive Officer and Director of AC Immune, describes here, current work is both establishing the targets that those vaccines must address…
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Nasal drugs show promise for slowing Parkinson’s disease
Two different peptides were found to slow the spread of alpha-synuclein, potentially becoming the first drugs to slow the progression of Parkinson’s disease.
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S1P may be a potential target for cerebral blood alterations
Sphingosine-1 phosphate was found to regulate blood glow in cerebral blood vessels in mice, presenting a potential therapeutic target.
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Drug development in stem cell-derived liver organoid models
To ensure that new drugs are effective and have as little toxicity as possible, they first need to be tested in model systems before entering clinical trials. In this Q&A, Dr Takanori Takebe outlines his research into liver organoids derived from stem cells that can be used to test new…
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Stem cell therapy repairs damage from dementia in mouse brains
Researchers have developed a stem cell therapy that could treat the damage caused by dementia by launching a repair response.
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Reduced levels of H2S in rat brains protects against dementia
A study has shown that treatments to reduce levels of hydrogen sulphide (H2S) in the brain may help to prevent dementia.
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Exploring new drug targets in Alzheimer’s disease
Although many potential targets have been identified for Alzheimer’s disease (AD), there is no effective treatment for this debilitating condition. In this article, Monika Schmidt and Sheraz Gul delve into the key proteins implicated in AD and suggest how phenotypic assays could aid in AD drug discovery.
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Antibody for amyloid beta oligomers could revolutionise Alzheimer’s field
Scientists have designed a high affinity antibody for pathogenic amyloid beta oligomers, a key driver of Alzheimer’s disease, for use in further research and as a potential diagnostic tool.
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Imaging technique allows study of early stage Alzheimer’s disease
Scientists used optical photothermal spectroscopy (O-PTIR) to image murine neurons affected by early stage Alzheimer’s disease, providing insight into the progression of the disease.
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Small molecule targeting mRNA could slow the progression of Parkinson’s disease
Research identified a small molecule that targets the mRNA of α-synuclein and prevents the formation of the protein, an approach which could provide novel neurodegeneration therapies.
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Alzheimer’s vaccine shows promising results in bigenic mice
Researchers have created a new combination vaccine therapy that can induce strong immune responses against tau and Aβ pathologies seen in Alzheimer’s in bigenic mice.
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Largest genome sequencing project launched in UK
The UK Biobank, the world’s largest genetics project, will sequence 500,000 genetic samples, which will be available to researchers everywhere.
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Revealed autophagy mechanism is potential dementia target
A study has discovered the regulating process behind cell autophagy which could aid in the development of neurodegenerative disease treatments.
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Encouraging drug discovery and therapeutic targets for dementia
A review has been published by experts in neurodegeneration research, detailing six ways to improve dementia research. This article investigates one of these suggestions, focusing on how we can improve drug target identification.
