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Alzheimer’s disease

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GAPSA reveals new HIV targets

28 February 2018 | By Drug Target Review

Researchers have developed the first-ever high-throughput, genome-scale imaging-based approach to investigate protein stability...

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Single-cell RNA sequencing provides molecular atlas to study brain diseases

15 February 2018 | By Dr Zara Kassam (Drug Target Review)

Researchers have detailed a molecular atlas of the cells that form the brain's blood vessels and the life-essential blood-brain barrier providing clues to which cell types are involved in different diseases...

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Depleting BACE1 reverse the formation of amyloid plaques in Alzheimer’s disease

14 February 2018 | By Dr Zara Kassam (Drug Target Review)

A team of researchers from the have found that gradually depleting an enzyme called BACE1 completely reverses the formation of amyloid plaques in the brains of mice with Alzheimer's disease...

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Nicotinamide riboside shows cognitive benefits in Alzheimer’s disease

7 February 2018 | By Dr Zara Kassam (Drug Target Review)

A form of vitamin B3 has been found to prevent neurological damage and improve cognitive and physical function in a new mouse model of Alzheimer’s disease...

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Study indicates holistic nature of Alzheimer’s disease (AD) progression

7 February 2018 | By Drug Target Review

A collaboration of scientists in the United States has identified a distinct association between inflammation biomarkers in blood plasma and cerebrospinal fluid (CSF), and markers of Alzheimer’s disease (AD).

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Raman imaging technique shows Alzheimer’s disease progress in the brain

24 January 2018 | By Drug Target Review

Using Raman optical technology, scientists can now produce images of brain tissue that is affected by Alzheimer’s disease...

Energy storehouses in the brain may be source of Alzheimer’s

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Energy storehouses in the brain may be source of Alzheimer’s

23 January 2018 | By Drug Target Review

Research into the effects of Alzheimer’s disease on how mitochondria structures function has revealed that a highly toxic beta amyloid protein disrupts normal function.

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Mitochondrial disease can be inherited from healthy parents

15 January 2018 | By Dr Zara Kassam (Drug Target Review)

Researchers have shown for the first time how children can inherit a severe -- potentially fatal - mitochondrial disease from a healthy mother...

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Healthy mitochondria may prevent Alzheimer’s disease

7 December 2017 | By Dr Zara Kassam (Drug Target Review)

Scientists have provided a therapeutic approach to slow down the progression of neurodegeneration in Alzheimer's disease...

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Anle138b blocks toxic ion flow linked to Alzheimer’s disease

5 December 2017 | By Dr Zara Kassam (Drug Target Review)

A new small-molecule drug can restore brain function and memory in a mouse model of Alzheimer's disease by stopping toxic ion flow in the brain...

New Alzheimer’s animal model more closely mimics human disease

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New Alzheimer’s animal model more closely mimics human disease

5 December 2017 | By Drug Target Review

Researchers have found that amyloid-? facilitates the interaction between the plaques and abnormal tau.

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Alzheimer’s Tau protein forms toxic complexes with cell membranes

22 November 2017 | By Dr Zara Kassam (Drug Target Review)

Researchers identify the sequence and structural factors that drive Tau interaction with membranes...

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SORLA protein protects against Alzheimer’s disease

7 November 2017 | By Dr Zara Kassam (Drug Target Review)

Researchers have identified a new protective function for a brain protein genetically linked to Alzheimer's...

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Declines in plasticity reveal promising targets for Alzheimer’s disease

26 October 2017 | By Dr Zara Kassam (Drug Target Review)

Brain changes linked to memory loss may provide a new focus for exploring ways to treat or prevent dementia...

news

yTRAP used to quantitatively measure and manipulate protein aggregation

23 October 2017 | By Dr Zara Kassam (Drug Target Review)

Researchers have built a synthetic genetic tool yTRAP to quantitatively sense, measure and manipulate protein aggregation in live cells...

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Alzheimer’s disease