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Acute Respiratory Distress Syndrome (ARDS)

What we know about COVID-19 and the inflammatory response

10 March 2021 | By Sadya Arnett (Scientific Writer)

A year on from discovering COVID-19 we are starting to understand why some people suffer more severely after infection. Sadya Arnett discusses recent research into the interconnection between host inflammation and SARS-CoV-2.

SARS-CoV-2 particle surrounded by red blood cells in a blood vessel - idea of COVID-19 causing blood clots

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Opaganib shows promise in preventing ARDS-induced thrombosis

16 December 2020 | By Hannah Balfour (Drug Target Review)

Opaganib reduced blood clot length and weight in a pre-clinical model of Acute Respiratory Distress Syndrome (ARDS).

SARS-CoV-2 viral particle (which causes COVID-19) circulating in the blood

news

Biomarkers for predicting COVID-19 disease severity

15 December 2020 | By Hannah Balfour (Drug Target Review)

Scientists have created a prognostic classification model which uses biomarkers to help predict an individual’s risk of developing severe COVID-19 symptoms.

surface of several coronavirus particles

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Novel target could treat both SARS-CoV-2 and other coronaviruses

10 December 2020 | By Hannah Balfour (Drug Target Review)

Scientists shows targeting cholesterol or phosphatidylinositol phosphate (PIP) could be a promising strategy to combat multiple coronaviruses.

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Investigating cellular pathways driving severe COVID-19 with proteomics

27 November 2020 | By Nikki Withers (Drug Target Review)

Researchers from Massachusetts General Hospital have studied several thousand circulating proteins within the plasma proteome of symptomatic COVID-19 patients and acutely ill non-COVID-19 controls. Nikki Withers discussed their findings and implications of the study with one of the lead authors, Dr Mike Filbin.

Blue antibodies surrounding a black SARS-CoV-2 particle with red Spike proteins on its surface

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Children produce a different antibody response to SARS-CoV-2 infection, finds study

6 November 2020 | By Hannah Balfour (Drug Target Review)

A new analysis reveals that the course of SARS-CoV-2 infection and the immune response it provokes is completely different in adults and children.

cartoon of a blood vessel with coronavirus particles attached to the lining of the vessel and a blood clot formed of red and white blood cells

news

Autoantibodies and over-active neutrophils may be cause of COVID-19 blood clots

3 November 2020 | By Hannah Balfour (Drug Target Review)

According to a new study, blood clots in patients with severe COVID-19 are caused by an autoimmune antibody that circulates in the blood and attacks cells.

SARS-CoV-2 particles in red over a research background - microscope, connical flask and test tubes in grey

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Severe COVID-19 symptoms may not be caused by cytokine storm

22 October 2020 | By Hannah Balfour (Drug Target Review)

An analysis reveals that in comparison to other inflammatory diseases such as cytokine-release syndrome (CRS) and sepsis, the levels of cytokines in severely ill COVID-19 patients is low.

doctor holding a SARS-CoV-2 particle next to a picture of lungs

news

Build-up in the lungs could be targeted by future severe COVID-19 treatments

7 October 2020 | By Hannah Balfour (Drug Target Review)

Breaking down or slowing the production of a hyaluronan jelly which builds up in the lungs of some severe COVID-19 patients could reduce respiratory distress and prevent death.

CBD structure with vials of oil and leaves from the cannabis plant

news

CBD may combat cytokine storms and respiratory distress caused by COVID-19

17 July 2020 | By Hannah Balfour (Drug Target Review)

Scientists found in a murine model of acute respiratory distress syndrome (ARDS) that cannabidiol (CBD) helped the lungs recover from excessive inflammation caused by COVID-19.

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Study identifies 68 genes associated with risk of severe COVID-19

26 June 2020 | By Victoria Rees (Drug Target Review)

A study has revealed 68 protein-coding genes associated with risk of severe COVID-19, nine of which are targeted by drugs currently in clinical trials.

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Rod-shaped microparticles could improve immune system response to COVID-19

11 June 2020 | By Victoria Rees (Drug Target Review)

Researchers have suggested that neutrophils, which contribute to the development of ARDS in COVID-19 patients, could be diverted from the lungs by rod-shaped particles in a new form of treatment.

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Severe COVID-19 symptoms may be caused by overactive neutrophils

16 April 2020 | By Hannah Balfour (Drug Target Review)

An international consortium suggest that the severe symptoms of COVID-19, including Acute Respiratory Distress Syndrome (ARDS), could be caused by Neutrophil Extracellular Traps (NETs).

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Lung study in mice points to new therapies to treat critical illness

10 May 2017 | By Niamh Marriott (Drug Target Review)

Scientists have pinpointed a chemical signal that worsens inflammation linked to a life-threatening lung condition. The discovery could eventually lead to new therapies for this disease, which can be fatal for up to half of those affected.

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Acute Respiratory Distress Syndrome (ARDS)