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Using virtual screening to identify coronavirus treatments

10 March 2020 | By Victoria Rees (Drug Target Review)

Drug Target Review rounds up the latest updates on research into coronavirus treatments, focusing on virtual screening to find therapies for COVID-19.

Developing an automatic microfluidic platform using ‘ferrobots’

9 March 2020 | By Victoria Rees (Drug Target Review)

A new microfluidic technology has been developed by researchers, which utilises magnetic ferrobots to automate chemical analyses and assays.

Discovering and designing drugs with artificial intelligence

4 March 2020 | By Victoria Rees (Drug Target Review)

The first drug designed using artificial intelligence (AI) has moved into its Phase I trial. Professor Andrew Hopkins of Exscientia explains how an algorithm was used to achieve this milestone.

tablets, syringes and drug vials surrounding the words 'autoimmune disease'

Rebalancing the immune system to treat autoimmune disease

2 March 2020 | By Hannah Balfour (Drug Target Review)

Dr Nicolas Poirier reveals how immunotherapies can be designed to recalibrate the immune system for long-term maintenance of autoimmune remission.

Y-shaped antibody interacting with cell surface

Why invest in creating a modifiable drug framework?

27 February 2020 | By Hannah Balfour (Drug Target Review)

Drug Target Review spoke with CUE Biopharma’s President and CSO to find out how and why they created the ImmunoSTAT platform and the ways it may benefit drug design in the future.

Could dolphins be viable models for human brain disorders?

25 February 2020 | By Professor Giovanni Di Guardo (University of Teramo)

Neuropathologic similarities between dolphins and humans suggest that the former could act as an effective model for the study of diseases such as Alzheimer’s. Professor Giovanni Di Guardo explains why dolphins could provide researchers with a new window into neurodegenerative conditons.

Novel molecules to adjust the circadian rhythm

20 February 2020 | By Victoria Rees (Drug Target Review)

A collaborative team of researchers has discovered two molecules that target the melatonin receptor, responsible for regulating the circadian rhythm. This article delves into their study and its therapeutic relevance for the body clock.

Discovering how drugs combat HIV and why resistance can occur

17 February 2020 | By Victoria Rees (Drug Target Review)

A group of researchers, led by Professor Zucai Suo, have revealed the mode of action of two HIV drugs and identified how resistance can develop, which they say could lead to improved drug design in the future.

hands coming together to create a lightbulb

ELRIG and the British Pharmacological Society: why form a strategic alliance?

14 February 2020 | By Hannah Balfour (Drug Target Review)

Here, the benefits of collaborating in drug discovery are explored through the strategic alliance between ELRIG and the British Pharmacological Society.

human torso anatomy with a cutaway of bacteria surrounding villi in the digestive tract

Could the gut microbiome be the key to new antidepressant therapies?

6 February 2020 | By Hannah Balfour (Drug Target Review)

Drug Target Review explores research that suggests the microbiome could be a therapeutic target for major depressive disorder and what treatment options are now in the pipeline as a result of this association.

Body-on-chip technology: resolving current limitations in drug discovery

30 January 2020 | By Victoria Rees (Drug Target Review)

Researchers have developed a new body-on-chip technology that can demonstrate the pharmacokinetics and pharmacodynamics of drugs in a pre-clinical setting without the need for animal testing.

The growing possibilities for stem cells in pharma

28 January 2020 | By Hannah Balfour (Drug Target Review)

Drug Target Review explores the latest applications of stem cells in modelling disease, drug production and the most recent steps in regenerative medicine provided by research.

Developing an algorithm to predict drug-induced liver injury

23 January 2020 | By Victoria Rees (Drug Target Review)

A collaboration between Elsevier and the FDA will present an algorithm for the accurate prediction of drug-induced liver injury. Drug Target Review investigates the benefits this toxicology project will bring to the drug discovery industry.

Could novel sex-linked targets provide an autoimmunity therapy?

20 January 2020 | By Hannah Balfour (Drug Target Review)

Recent research into why autoimmune disorders affect women four times more frequently than men has revealed several novel therapeutic targets that may lead to the development of future treatments.

Five of the latest cancer stem cell discoveries

15 January 2020 | By Victoria Rees (Drug Target Review)

Oncologic stem cells have been identified in many malignancies, and targeting these cells could help in the fight against cancer. Here are five of the most recent findings regarding cancer stem cells.

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