Expert view: Generate high‑content information using flow cytometry

Posted: 11 September 2018 | | No comments yet

Flow cytometry has become a widely used technology in life science research since its development in the 1970s. It is also essential for many biopharmaceutical and biotechnology companies due to its proficiency in identifying biomarkers, finding new inhibitory antibodies, and assessing the efficiency of new pharmacological protocols.

R&D faces a major challenge to keep costs low while still advancing treatment strategies. These strategies can only be identifi ed with more detailed analysis of biological mechanisms, cell populations and the mechanism of action of new molecules.

Addressing such challenges requires fast solutions that offer high‑throughput multiparametric analysis. Furthermore, the wide variety of experimental protocols developed to answer scientific and pharmacological questions requires flexible instruments. Finally, these solutions should be accessible to even non-experienced researchers.

In the past, flow cytometers have been able to deliver detailed analysis of multiple parameters despite limitations in terms of throughput and number of samples analysed. The Bio-Rad ZE5 Cell Analyser represents a technological breakthrough that enables industrial laboratories to efficiently design different protocols and analyse experiments faster. The system’s integrated sample loader can switch from tubes to up to 384-well plates in seconds. Paired with its unparalleled speed that can detect up to 100,000 events per second, it is ideal for screening. Its 30‑parameter capability delivers a large amount of data from every cell of all the samples. When in use, the ZE5 Cell Analyser’s companion software offers user‑friendly features such as the Spectral Viewer for experiment design and QC checks with the ZE5 EYE. All these features will increase productivity and efficiency while driving to new discoveries. This five-minute video gives an extensive overview of the ZE5 Cell Analyser as well as an exclusive insight from the perspective of other users:

For busy and innovative biopharma laboratories, the ZE5 is the ideal system.