Whitepaper: Phenotypic drug discovery with high content screening
Reasons for phenotypic vs. target based drug discovery strategies, challenges of and maximising return of phenotypic assays.
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Whitepapers
Application note: Distinguishing cell types by phenotypic profiling
Describing how a single nuclear stain can enable phenotypic profiling for new and additional perspectives on assays at no extra cost.
Tech note: Benefits of water immersion lenses for HCS
Water immersion lenses provide: brighter images from HCS samples; faster and gentler imaging; higher quality images from both 2D and 3D samples.
Poster: Expansion of human induced pluripotent stem cells in scalable stirred suspension culture
12 January 2018 | By MilliporeSigma
Expansion of hiPSCs as aggregates in stirred suspension...
Poster: Expansion of human induced pluripotent stem cells in scalable stirred suspension culture
12 January 2018 | By Merck
Expansion of hiPSCs as aggregates in stirred suspension...
Application note: Functional GPCR studies using AlphaScreen cAMP Detection Kit
In this application note, PerkinElmer demonstrates the ease and utility of the AlphaScreen® cAMP assay for detecting both agonist and antagonist-induced cAMP responses within cells.
Application note: LANCE Ultra TR-FRET – based detection and modulation of Phosphorylated STAT3 levels in human cells
In this application note, PerkinElmer demonstrates how LANCE® Ultra, a homogeneous assay format, can be used to quickly and accurately assess modulation of pSTAT3.
Application note: Fc-Receptor binding in ADCC assays utilising LANCE Ultra Technology – characterisation of hIGs and FcγRIIIa
In this application note, PerkinElmer demonstrates the ease and utility of using LANCE® Ultra, a homogeneous assay format, for determining binding profiles of therapeutic monoclonal antibodies to FcγRs.
Application note: High throughput quantitation of cytokine biomarkers using LANCE Ultra TR-FRET assays
In this application note, PerkinElmer demonstrates the sensitivity, robust performance, and HTS suitability of the LANCE Ultra cytokine biomarker kits.
Application note: Development and utilisation of bromodomain and extra terminal domain (BET) assays using AlphaLISA technology
In this application note, PerkinElmer demonstrates the ease and utility of using AlphaLISA®, a homogeneous assay format, to screen for small molecular inhibitors of BET bromodomains.
Scientific poster: Developing protein: Protein Interaction (PPI) assays with AlphaLISA and LANCE TR-FRET
In this scientific poster, PerkinElmer demonstrates the ease and utility of using AlphaLISA® and LANCE® TR-FRET homogenous assay forms for studying PPIs.
Application note: Performing NanoBRET with the Varioskan LUX multimode reader
In this paper, Thermo Fisher Scientific aim to assess the performance of Thermo Scientific Varioskan LUX when running NanoBRET.
Application note: Screening for inhibitors of PD-1 and PD-L1 binding with AlphaLISA technology
In this application note, PerkinElmer demonstrate the utility of an AlphaLISA assay for screening biotherapeutic antibodies and compounds that block binding of human PD-1 and PD-L1.
Application note: KingFisher sample purification system
Next generation sequencing sample preparation on the KingFisher platform...
Scientific article: iPSC Cells
An entirely new area of stem cell biology was introduced by Shinya Yamanaka in 2006 when he discovered that somatic cells could revert back to pluripotent-like cells, or induced pluripotent stem cells (iPSCs).
