Poster: Positive allosteric modulators of GABAA
Posted: 1 July 2016 | Charles River Laboratories | No comments yet
Selective and non-selective positive allosteric modulators were evaluated for their effects on GABAA α1β1γ2L and α1β2γ2L subtypes…
GABAA receptors are targets for drugs used for treatment of anxiety disorders.
Many of the drugs function as positive allosteric modulators (PAMs) of GABA, potentiating the inhibitory activities of the ligand and channels within the CNS. Although some PAMs are relatively non-selective, others have been reported to preferentially potentiate channels containing β2 subunits over those containing β1 subunits. In this study, we evaluated selective and non-selective PAMs, for their effects on HEK293 and CHO cells expressing GABAA α1β1γ2L and α1β2γ2L subtypes.
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