Transforming translational research: CANscriptTM – A better predictive model for oncology
Supported by:
17 May 2018
ABOUT THIS WEBINAR
In this webinar, speaker Mark Paris, PhD discussed a recent study evaluating a cohort of HNSCC patient tumours treated with anti-PD1 using CANscript™. He also be reviewed the results of this study as a means of investigating predictors of clinical response and identifying mechanisms of resistance.
Delineation of the intra-tumour microenvironment in a dynamic, spatio-temporal setting is critical for investigating the activity and efficacy of candidate oncology drugs. The majority of solid cancers contain unorganised, highly-complex microenvironment wherein a dysregulated phenotypic impacts treatment outcomes at a personalised level.
We have developed and validated a fully human ex-vivo platform technology (CANscript™) using patient material (tumour, autologous ligands and immune cells) to explore the mechanism of and predict efficacy for clinically-directed compounds across several drug classes (Nat Comm., 6:6169:1-14 2015).
Drugs that modulate the immune system have been shown to be very effective in some patients. Tumour Infiltrating Lymphocytes are often required for the function of these drugs. In order to understand the role of functional immune phenotypes, we evaluated a cohort of HNSCC patient tumours treated with anti-PD1 using CANscript™.
This session reviewed results of this study as a means of investigating predictors of clinical response and identifying mechanisms of resistance.
KEYNOTE SPEAKER
Mark Paris, PhD, Associate Director, Translational Applications, Mitra Biotech
Mark is the technical lead for Mitra’s biopharma marketing effort and works with clients to craft custom solutions for their drug development needs. He spent 16 years in commercial antibody discovery and clinical development focusing on immuno-oncology. He has >12 years of experience running core molecular and immunohistochemistry labs. He is a graduate of Case Western Reserve University with a Ph.D. in Genetics.
The rest of this content is restricted - login or subscribe free to access
Thank you for visiting our website. To access this content in full you'll need to login. It's completely free to subscribe, and in less than a minute you can continue reading. If you've already subscribed, great - just login.
Why subscribe? Join our growing community of thousands of industry professionals and gain access to:
- quarterly issues in print and/or digital format
- case studies, whitepapers, webinars and industry-leading content
- breaking news and features
- our extensive online archive of thousands of articles and years of past issues
- ...And it's all free!
Click here to Subscribe today Login here
Related topics
Drug Discovery, Drug Discovery Processes, ex-vivo, Molecular Biology, Molecular Targets, Oncology, Personalised Medicine, Precision medicine, Research & Development, Translational Science
Related organisations
Mitra Biotech
Related people
Mark Paris
I am pleased to announce that the on demand version of this webinar is now available to watch. Should you have any feedback, please let us know in the comments below.