news Frizzled receptors could be drug targets for treating major diseases 5 December 2018 | By Iqra Farooq (Drug Target Review) Frizzled receptors, from the GPCR family, could soon be a target to treat numerous diseases such as cancer, fibrosis and CVD...
article PAINS management: an open source model to eliminate nuisance compounds 4 December 2018 | By Stephen J. Capuzzi and David C. Morris (Eshelman School of Pharmacy - University of North Carolina Chapel Hill) High-throughput screening (HTS) technologies have enabled the routine testing of millions of compounds towards the identification of novel ‘hit’ molecules for therapeutic targets. Oftentimes in this drug discovery process, however, compounds that show promising activity in primary screens show no activity during subsequent hit qualification or progression efforts.
news Nanoscale ‘tweezers’ for individual cell biopsies 4 December 2018 | By Iqra Farooq (Drug Target Review) Researchers have developed nanoscale 'tweezers' used to investigate single living cells, which could help to identify why healthy cells become diseased...
news T-cells engineered to recognise tumours expressing the CD30 protein marker 4 December 2018 | By Drug Target Review Researchers have genetically engineered immune cells to recognise and fight Hodgkin and non-Hodgkin lymphoma cells...
news Digital 3D brain cell atlas released 30 November 2018 | By Fraser Owen (Drug Target Review) The Blue Brain 3D atlas could be the future of analysing all cells in the brain, with high quality, high resolution images that can navigate the brain...
news High-throughput platform could map cancer drug target activity 30 November 2018 | By Drug Target Review Manchester University researchers have developed a high-throughput platform to analyse and study a family of enzymes that are linked to cancer...
whitepaper Application note: Integrated biologics – Enabling high-throughput drug discovery at Amgen with Thermo Fisher™ Platform for Science™ Software 29 November 2018 | By Thermo Fisher Scientfic Every day scientists are working to discover and develop new therapies and treatments to change the lives of patients suffering from serious and debilitating illnesses. Amgen Inc. has made it a priority to unlock the potential of biology to discover, develop, manufacture, and deliver innovative therapeutics to patients.
whitepaper Application note: Transforming your bioanalysis operations – is a lack of insight slowing you down? 29 November 2018 | By IDBS Many bioanalytical labs work with a crowded and siloed set of systems and processes. From part electronic to part paper-based workflows to standalone point-solutions, the result is a lack of insight into data and slower reporting and results handling.
news Starving lung cancer could be an effective treatment 29 November 2018 | By Drug Target Review A recently discovered enzyme could lead to the development of a treatment where cancer cells are starved of 'food' provided by this protein...
news Supercoils in DNA could give insights to antibiotic drug development 28 November 2018 | By Drug Target Review DNA gyrase, a molecular machine used to prevent DNA from coiling, could be used to ensure bacterial DNA coils, reducing the risk of infection to humans...
news Cryoablation could treat low risk breast cancer 28 November 2018 | By Drug Target Review A study by Princeton Radiology researchers has found that cryoablation could be effective in targeting low risk breast cancer...
news Freeze-dried vaccine may help eradicate polio 27 November 2018 | By Drug Target Review Researchers have developed a polio vaccine that doesn't require refrigeration, meaning it could someday be used all over the world...
news Transporting proteins into cells to mitochondria 26 November 2018 | By Drug Target Review J-proteins such as Xdj1, as helpers of the heat shock protein 70 chaperones, and were found to be involved in the transport of proteins to the mitochondria...
news Breast cancer recruits cells from bone marrow to boost growth 23 November 2018 | By Drug Target Review A study has shown that breast cancer uses stromal cells originally formed in bone marrow to boost their growth and metastasis of the cancer...
news Study reveals 35 genes linked to chronic kidney disease 23 November 2018 | By Drug Target Review A study conducted by researchers at The University of Manchester and Manchester Children's Hospital has revealed 35 genes linked to chronic kidney disease...
