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Inhalable mRNA could treat lung disease
An inhalable mix of a polymer and mRNA molecules, used to produce luciferase, could be the method of treating lung diseases in the future...
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Therapeutics
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Editing enzyme could promote tumour suppressor loss
The detection of 'copy editing' by a stem cell enzyme in over 20 tumour types could be a biomarker and possible therapeutic target for certain cancers...
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Triple-negative breast cancer could be treated using experimental treatment
A mouse study has revealed that triple-negative breast cancer could be tackled by using recombinant Tinagl1 in therapy targeting signalling pathways...
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The mysterious functions of the PCSK9 protein
Researchers have described the methods used to build a model of the 'druggable' PCSK9 inhibitor and detailed how it works...
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Implantable device could treat bladder problems
A tiny, soft, implantable device could be used to treat and control bladder problems, such as incontinence or the need to frequently urinate...
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Using machine learning to predict symptoms
Machine learning could, in future, be the way that clinicians decide on particular courses of treatments for patients affected by cancer...
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Potential drug targets found by muting large silent genes
Streptomyces bacteria has been used to identify compounds that could lead to the production of drugs to treat various conditions...
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Application note: Rapidly isolate high-producing clones
Find out how to streamline Cell Line Development by identifying high-producing clones with monoclonality assurance in one day.
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Drug targets for Dengue, Zika and Ebola viruses
US researchers have identified possible drug targets for Dengue, Zika and Ebola viruses…
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Vaccine could combat opioid addiction and reduce deaths
Researchers have developed a vaccine to combat the opioid epidemic and to prevent deaths, with possible applications of the vaccine in many areas...
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Ingestible capsule controlled wirelessly could treat diseases
Researchers have designed a drug delivery capsule that can stay in the stomach for up to 1 month, and could sense and treat infections...
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Calcium carbonate sprayable gel could fight cancer
A sprayable gel containing calcium carbonate nanoparticles with an antibody specifically targeted to block CD47, could be the future of cancer treatments...
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Beyond ‘simple’ biology – turning organoids, spheroids, and 3D tissue models into physiologically relevant high-content assays for drug discovery
Drug discovery is still hampered by the routine use of cell-based models that often fail to recapitulate the truly relevant biological complexity of the corresponding disease. Just moving from two- (2D) towards three-dimensional (3D) cell culture model systems like spheroids and organoids is not enough to generate truly representative and…
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Phospholipid reactive T-cells could play a role in cancer
Phospholipid-reactive T-cells that are able to recognise phospholipids could help in treatments against cancer, autoimmune diseases and dyslipidemia...
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Expert view: Challenges in drug discovery screening
The basic premise of drug discovery screening necessitates that the biological assays upon which it depends can be performed in a reproducible manner. In addition, the techniques employed must generate results that are biologically relevant and actionable.
