news Inhalable mRNA could treat lung disease 7 January 2019 | By Iqra Farooq (Drug Target Review) An inhalable mix of a polymer and mRNA molecules, used to produce luciferase, could be the method of treating lung diseases in the future...
news Editing enzyme could promote tumour suppressor loss 4 January 2019 | By Drug Target Review The detection of 'copy editing' by a stem cell enzyme in over 20 tumour types could be a biomarker and possible therapeutic target for certain cancers...
news Triple-negative breast cancer could be treated using experimental treatment 4 January 2019 | By Drug Target Review A mouse study has revealed that triple-negative breast cancer could be tackled by using recombinant Tinagl1 in therapy targeting signalling pathways...
news The mysterious functions of the PCSK9 protein 3 January 2019 | By Drug Target Review Researchers have described the methods used to build a model of the 'druggable' PCSK9 inhibitor and detailed how it works...
news Implantable device could treat bladder problems 3 January 2019 | By Iqra Farooq (Drug Target Review) A tiny, soft, implantable device could be used to treat and control bladder problems, such as incontinence or the need to frequently urinate...
news Using machine learning to predict symptoms 2 January 2019 | By Iqra Farooq (Drug Target Review) Machine learning could, in future, be the way that clinicians decide on particular courses of treatments for patients affected by cancer...
news Potential drug targets found by muting large silent genes 2 January 2019 | By Iqra Farooq (Drug Target Review) Streptomyces bacteria has been used to identify compounds that could lead to the production of drugs to treat various conditions...
whitepaper Application note: Rapidly isolate high-producing clones 21 December 2018 | By Sphere Fluidics Ltd. Find out how to streamline Cell Line Development by identifying high-producing clones with monoclonality assurance in one day.
news Drug targets for Dengue, Zika and Ebola viruses 14 December 2018 | By Drug Target Review US researchers have identified possible drug targets for Dengue, Zika and Ebola viruses…
news Vaccine could combat opioid addiction and reduce deaths 14 December 2018 | By Drug Target Review Researchers have developed a vaccine to combat the opioid epidemic and to prevent deaths, with possible applications of the vaccine in many areas...
news Ingestible capsule controlled wirelessly could treat diseases 13 December 2018 | By Drug Target Review Researchers have designed a drug delivery capsule that can stay in the stomach for up to 1 month, and could sense and treat infections...
news Calcium carbonate sprayable gel could fight cancer 12 December 2018 | By Drug Target Review A sprayable gel containing calcium carbonate nanoparticles with an antibody specifically targeted to block CD47, could be the future of cancer treatments...
article Beyond ‘simple’ biology – turning organoids, spheroids, and 3D tissue models into physiologically relevant high-content assays for drug discovery 11 December 2018 | By Matthias Nees and Malin Åkerfelt (University of Turku - Finland) Drug discovery is still hampered by the routine use of cell-based models that often fail to recapitulate the truly relevant biological complexity of the corresponding disease. Just moving from two- (2D) towards three-dimensional (3D) cell culture model systems like spheroids and organoids is not enough to generate truly representative and…
news Phospholipid reactive T-cells could play a role in cancer 7 December 2018 | By Drug Target Review Phospholipid-reactive T-cells that are able to recognise phospholipids could help in treatments against cancer, autoimmune diseases and dyslipidemia...
article Expert view: Challenges in drug discovery screening 6 December 2018 | By Steven Jarvis (Scientific Director - Global Strategic Accounts at Merck) The basic premise of drug discovery screening necessitates that the biological assays upon which it depends can be performed in a reproducible manner. In addition, the techniques employed must generate results that are biologically relevant and actionable.
