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Machine-learning model to analyse protein sequences
A machine-learning model has been developed to analyse protein sequences, giving an insight to their structure, function and phylogeny...
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Therapeutics
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Potential EBV-associated cancer treatment in small molecule inhibitors
A small molecule inhibitor has been observed to activate a dramatic reduction in tumour growth in EBV-associated tumours...
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Anthelmintic drug niclosamide repurposed to treat Helicobacter pylori
Researchers have repurposed use of niclosamide to treat Helicobacter pylori cell lines, focusing on how it is effective in infection models...
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Genomics to match treatments to pancreatic cancer patients
Genomics could be used to match drugs to patients better, with these genetic signatures also giving an earlier insight into detection of the condition...
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Protein marker in response to brain cancer therapy
An extremely powerful MRI scanner was used to image proteins in the brain of cancer patients and has shown that protein content correlates with treatment...
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Colon cancer pathway discovery could lead to targeted therapies
Researchers have pinpointed a set of enzymes involved in tumor growth that could be targeted to prevent or treat colon cancer...
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Counteracting T-cell exhaustion in CAR-T cancer therapies
Engineered T-cells that target NFAT and Nr4a proteins could help to prevent the exhaustion of T-cells during CAR-T immunotherapy...
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Secret life of antimicrobial peptide revealed through CRISPR
Antimicrobial peptides were found to act against Gram-negative bacteria and certain fungi by working either together or by adding up their individual effects...
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Book mechanism identified as communication method for bacterial toxins
Researchers have identified the mechanism by which highly toxic compounds communicate, and how they use vesicles to be transported...
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MRI sensor to image activity deep inside the brain
A method of imaging calcium activity that is based on magnetic resonance imaging (MRI) could help to image deep within the brain...
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Taking a BiTE out of lung cancer
Bispecific T-cell engager technology (BiTE) could be used to quickly and accurately diagnose patients suffering from lung cancer...
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Gene therapy to reduce deafness in mice
Gene therapy has been used to restore hearing in an adult mouse model of DFNB9 deafness, one of the most frequent cases of congenital genetic deafness...
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Fighting HIV using anti-cancer immunotherapy
Researchers have used immunotherapy treatments, ordinarily used to treat cancer, to reveal the virus in the cells of people living with HIV...
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How the immune cell ‘Iron Man’ helps T-cells fight infection
The Iron Man of immune cells, the CD4 cell, has been found to help T-cells fight viral infections, with a lack of these cells often leading to illness...
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Immunotherapy and DNA damage repair combo could target lung cancer
Combination therapy with a CHK1 or PARP inhibitor, with an immune checkpoint inhibitor caused the regression of small cell lung cancer in all mice treated...
