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Methodology developed to genetically modify lab mice and human cells
A method designed to genetically alter laboratory mice can also be used to produce personalised animal models of an aggressive type of malignant brain cancer in children.
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Therapeutics
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Therapeutic antibodies in cancer therapy
Monoclonal antibodies have shown great promise in the treatment of various cancers. This article discusses how therapeutic antibodies are produced and the various treatment strategies that are currently being adopted.
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Expert view: Opportunities in flow cytometry
New therapies that direct the immune system to identify and destroy cancer cells, such as CAR-T and immune checkpoint inhibitors, have revolutionised cancer treatment.
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Expert view: Engineered antibodies: semi-rational design approach for faster optimisation
A significant hurdle in optimising antibody therapeutics is the screening of successive rounds of large libraries of mutant variants in order to recognise the ideal candidate.
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Expert view: Call to action: establishing the protein-binding properties of oligonucleotides
The number of oligonucleotide-based platforms on the market is constantly increasing and has led to the emergence of innovative nucleic acid-based therapeutic modalities such as CRISPR-Cas, sgRNAs or mRNAs.
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Therapeutic target for Kennedy’s disease and prostate cancer proposed
A chaperone protein has been identified as a possible therapeutic target for the treatment of Kennedy's disease and prostate cancer.
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Industry objects to unproven T-cell preservation services
The ISCT is objecting linking the benefits of cellular immunotherapy with third party offerings of T-cell banking for future therapeutics.
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New drug could be used for targeted cancer therapies
A new drug called IP1867B, which could be used for future treatments of brain tumours, is being examined.
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Researchers grow genetically engineered mini livers to study disease
The first genetically modified mini human livers have been grown in a laboratory, to emulate liver disease progression and test therapeutics.
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Two therapeutic targets identified for lung cancer
Salk scientists discover a pair of enzymes that drive non-small-cell lung cancer by promoting inflammation which could inform the development of new therapies.
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Secondary structures study could lead to making cancer cells vulnerable
Researchers have used machine learning to discover that the two most widespread DNA structures cause genome mutations that lead to cancer.
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Natural antioxidant helps improve immune-based therapies
Scientists have discovered a way to improve immune-based treatments by modulating T cells.
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Crystals mapped to advance treatments for stroke, diabetes and dementia
Researchers haved mapped the crystal structure of a protein to find out how a drug latches onto it.
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Why do we have no effective treatments for osteoarthritis?
Osteoarthritis (OA) is a painful and debilitating disease of articular joints.1,2 Its clinical prevalence is as high as 21.6 percent of the population in the United States,3 which constitutes direct health costs of over 80 billion US dollars annually.4
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Paving the path towards precision medicine
A method to view the immune cell 'landscape' of bowel cancer tumours could pave the way towards more individualised medicine and treatment...
