news Non-opioid based target identified to potentially treat chronic pain 27 May 2021 | By Victoria Rees (Drug Target Review) Researchers have discovered that blocking TRPC5 activity treated chronic pain in mouse models of various conditions.
news SARS-CoV-2 RNA analysis reveals potential treatment targets 26 May 2021 | By Victoria Rees (Drug Target Review) Researchers have explored the interaction between SARS-CoV-2 RNA and the host cell, uncovering possible targets to prevent viral replication.
news GRP78 molecular chaperone revealed as drug target for COVID-19 25 May 2021 | By Victoria Rees (Drug Target Review) Using computer modelling, a team has shown that a molecular chaperone called GRP78 could be targeted by drugs in strategies to treat COVID-19.
news Novel inhibitor blocks myeloma cancer cell growth in mouse model 18 May 2021 | By Victoria Rees (Drug Target Review) Having identified the histone demethylase KDM5A as a multiple myeloma target, researchers developed a KDM5 inhibitor to treat the cancer.
news Researchers reveal frameshifting as SARS-CoV-2 drug target 14 May 2021 | By Victoria Rees (Drug Target Review) A critical stage of the SARS-CoV-2 replication process, known as frameshifting, could be targeted by new drugs, researchers say.
news Mitochondrial enzyme found to block ferroptosis, presenting cancer target 13 May 2021 | By Victoria Rees (Drug Target Review) The mitochondrial enzyme dihydroorotate dehydrogenase (DHODH) can block cell death, new research has shown, making it a cancer drug target.
news Scientists design new drug compound to combat malaria 12 May 2021 | By Victoria Rees (Drug Target Review) Researchers have developed a set of compounds designed to stop the malaria parasite being able to burst out of red blood cells and replicate.
news Second mechanism of action discovered for COVID-19 drug remdesivir 11 May 2021 | By Victoria Rees (Drug Target Review) Researchers have found that a metabolite of remdesivir potentially targets a SARS-CoV-2 protein involved in suppressing the host cell's defence response.
webinar Cellular Thermal Shift Assays – bringing relevant target engagement to your drug discovery workflow 11 May 2021 | By PerkinElmer Get the Big Picture and listen to Pharma thought leaders how they view CETSA® and its impact on their Drug Discovery.
news Computational epitope map of SARS-CoV-2 Spike protein developed 7 May 2021 | By Victoria Rees (Drug Target Review) Researchers have produced a computational simulation of the SARS-CoV-2 Spike protein, finding spots that glycans do not cover.
news Team identifies potential drug to repurpose against melanoma 13 April 2021 | By Victoria Rees (Drug Target Review) Researchers say that inhibiting NLRP3 with Dapansutrile could be an effective strategy to prevent melanoma tumour growth.
news Researchers discover strategy to reverse poor stress response in mice 8 April 2021 | By Victoria Rees (Drug Target Review) Studying the mouse gene Ophn1, researchers have found its removal causes stressed behaviours, also identifying three ways to reverse this effect.
news Drugs with potential to stop plaque build-up in arteries identified 26 February 2021 | By Victoria Rees (Drug Target Review) A new compound can inhibit the build-up of plaque in arteries and prevent atherosclerosis, researchers have shown.
news NAD depletion by IFN sensitises pancreatic cancer to NAMPT inhibition, study shows 19 February 2021 | By Victoria Rees (Drug Target Review) High IFN signalling in pancreatic tumours are sensitive to NAMPT inhibitors which block a pathway in NAD synthesis, presenting a drug target.
news New drug combination could combat Diffuse Intrinsic Pontine Glioma 17 February 2021 | By Victoria Rees (Drug Target Review) The drug combination of difluoromethylornithine and AMXT 1501 has shown success against Diffuse Intrinsic Pontine Glioma in animal models.
