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Target molecule

news

Study identifies potential therapy for a common cause of dementia

13 July 2018 | By Drug Target Review

Early-stage research has uncovered a potential approach to treat one of the commonest causes of dementia and stroke in older people...

whitepaper

Whitepaper: Opportunities in preclinical development

11 July 2018 | By IDBS

This whitepaper explains how you can find ways to optimise the holistic preclinical development process...

news

New cancer immunotherapy shows promise in early tests

3 July 2018 | By Dr Zara Kassam (Drug Target Review)

Researchers report that in preclinical models they can amplify macrophage immune responses against cancer using a self-assembling supramolecule...

news

CLR01 protein found in semen increases the spread of Ebola virus infection

26 June 2018 | By Drug Target Review

Penn study suggests that targeting amyloid fibrils could prevent sexual transmission...

news

Targeting cPLA2 may improve the treatment of epilepsy

10 May 2018 | By Drug Target Review

New findings demonstrate that there may be ways to address blood-brain barrier dysfunction in epilepsy...

news

FGF21 gene variant found to lower body fat

11 April 2018 | By Drug Target Review

Researchers have found that a gene that makes humans eat more sugar can also lower body fat...

news

Animal model of Huntington’s offers advantages for testing treatments

2 April 2018 | By Dr Zara Kassam (Drug Target Review)

Using genetic engineering technology, a team of scientists have established an animal model of Huntington's disease...

news

Scientists discover promising off-switch for inflammation

30 March 2018 | By Dr Zara Kassam (Drug Target Review)

Scientists have discovered that itaconate - a molecule derived from glucose - acts as a powerful off-switch for macrophages...

whitepaper

Application note: Simultaneous dual phosphoprotein target analysis with Alpha Terbium SureFire Ultra Multiplex

20 March 2018 | By Andrea Brown (TGR BioSciences), Antony Sheehan (TGR BioSciences), Michael Crouch (TGR BioSciences), Vincent Dupriez (PerkinElmer)

This application note discusses how the Alpha SureFire® Ultra™ Multiplex technology provides a phosphoprotein multiplexing detection platform that is truly homogeneous and high throughput.

article

Expert view: Toward physiological relevance in drug discovery and development

19 March 2018 | By Anis H. Khimani (PerkinElmer)

Physiologically relevant screening models have become increasingly important in assay development and the screening of drug candidates.

news

Controlling ceramides could help treat lipotoxic cardiomyopathy

8 March 2018 | By Dr Zara Kassam (Drug Target Review)

Study of Drosophila links ceramide accumulation to heart dysfunction...

news

GAPSA reveals new HIV targets

28 February 2018 | By Drug Target Review

Researchers have developed the first-ever high-throughput, genome-scale imaging-based approach to investigate protein stability...

news

MeXis gene may protect against heart disease

16 February 2018 | By Dr Zara Kassam (Drug Target Review)

Scientists have identified a gene that may play a protective role in preventing heart disease...

news

Chondroitin sulphate nets hold promise for heart failure treatments

2 February 2018 | By Dr Zara Kassam (Drug Target Review)

Researchers discover molecular nets inside heart muscles which hold promise for new heart failure treatment...

Researchers identify new melatonin-based molecular targets for design of new drugs against Parkinson's

news

Researchers identify new melatonin-based molecular targets for design of new drugs against Parkinson’s

15 January 2018 | By Drug Target Review

A team of scientists has published the results of a new breakthrough in molecular mechanisms of the anti-parkinsonian activity of melatonin.

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