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Exosome formulation developed for choroidal neovascularisation therapy

27 July 2021 | By Anna Begley (Drug Target Review)

An exosome formulation has been created to deliver vascular endothelial-growth factor (VEGF) antibodies for choroidal neovascularisation therapy in models.

news

Inhibiting PIP4K enzymes could help immune system fight cancer

27 July 2021 | By Anna Begley (Drug Target Review)

Researchers identified a potential therapeutic involving the inhibition of PIP4K enzymes which could enable the immune system to destroy tumour cells.

news

Bacterial metabolites could increase tumour therapy efficiency

22 July 2021 | By Anna Begley (Drug Target Review)

Bacterial metabolites showed an increase in the cytotoxic activity in immune cells that could potentially influence efficiency of tumour therapies.

Cancer cell - lentivirus vector treatment

article

Lentiviral vectors: the key to cancer treatments that CAR T-cell therapy cannot reach?

21 July 2021 | By Professor Christian Brechot (TheraVectys)

Professor Christian Brechot explains why lentiviral vectors could serve as an effective tool for treating a wide range of cancers and could be used for vaccines.

news

T_reg cells could be answer to multiple sclerosis treatments, say scientists

21 July 2021 | By Anna Begley (Drug Target Review)

New research has shown that the protein Piezo 1 prevented Treg cells from controlling the effects of inflammation in a multiple sclerosis mouse model.

news

Metabolic pathway could potentially enhance vaccine effectiveness

8 July 2021 | By Anna Begley (Drug Target Review)

A metabolic control pathway that regulates T follicular helper cells could enhance vaccine effectiveness, including those that protect against COVID-19.

news

Stem cells used to enhance immune response to HIV in primates

24 June 2021 | By Victoria Rees (Drug Target Review)

In non-human primates, researchers have found that mesenchymal stem cells were effective at strengthening the immune response to HIV.

news

Common antidepressant drugs fight cancer in mice, study shows

11 June 2021 | By Victoria Rees (Drug Target Review)

Monoamine oxidase inhibitors can block the function of a protein, helping T cells to effectively fight cancer, a study in mice has shown.

news

Newly identified protein could become target for cancer immunotherapy

7 June 2021 | By Victoria Rees (Drug Target Review)

Researchers have found a protein that, when inhibited in mice with cancer, increased the response to immunotherapy.

article

Monitoring the potency of cell therapies using bioelectronic assays

24 May 2021 | By Dr Jim Ross (Axion Biosystems)

Chimeric antigen receptor (CAR) T and natural killer (NK) therapies may become the future of cancer treatment. Dr Jim Ross explains how bioelectronic assays are a non-invasive, label-free approach built for real-time, dynamic assessment of cell therapy potency.

news

Self-assembling nanofibres could prevent damage from inflammation

15 April 2021 | By Victoria Rees (Drug Target Review)

A team has demonstrated in mouse models that a self-assembling nanofibre material could limit the damage caused by cytokines in inflammatory diseases.

article

Immunosurveillance and the importance of CD4 T cells in developing cancer vaccines

1 April 2021 | By Dr Lien Lybaert (myNEO)

In this article, Dr Lien Lybaert describes how the innate and adaptive immune system work together to produce an effective and durable antitumour response. She explains why the best strategy for personalised cancer therapy is therefore to identify major histocompatibility (MHC) binding epitopes to cover the full antigenic repertoire of…

article

Glycolytic-pathway inhibition and CTLA-4 blockade to improve immuno-oncology

31 March 2021 | By Dr Taha Merghoub (Memorial Sloan Kettering; Ludwig Cancer Research)

In this Q&A, Dr Taha Merghoub discusses how a combination of glycolytic-pathway inhibition and immune checkpoint blockade using anti-CTLA-4 in patients with highly glycolytic tumours could present a personalised approach for immuno-oncology.

article

The development of biomaterial-based vaccine platforms against viruses

31 March 2021 | By Dr Kaushik Chatterjee (Indian Institute of Science), Dr Sonal Asthana (Indian Institute of Science), Dr Sushma Kumari (Indian Institute of Science)

Recent years have seen an increase in the development of biomaterial and nanoparticle-based vaccine formulations. Sushma Kumari, Sonal Asthana and Kaushik Chatterjee from the Department of Materials Engineering at the Indian Institute of Science discuss why these materials have such high potential in the fight against infectious diseases.

news

CD8⁺ T cells recognise recent SARS-CoV-2 variants, scientists say

31 March 2021 | By Victoria Rees (Drug Target Review)

Researchers have revealed that T cells in blood samples from people who recovered from COVID-19 responded to SARS-CoV-2 variants.

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