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Structural biology

Determining the structure of nanobodies using nuclear magnetic resonance spectroscopy

23 September 2021 | By Professor Gennaro Esposito (NYU Abu Dhabi)

Scientists at the New York University (NYU) Abu Dhabi have used nuclear magnetic resonance (NMR) techniques to determine the structure of a specific nanobody, Nb23. Drug Target Review’s Victoria Rees spoke with lead researcher Professor Gennaro Esposito to find out how their findings could lead to a better understanding of…

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Researchers simulate hepatitis B infection using computational method

8 September 2021 | By Anna Begley (Drug Target Review)

The new study modelled the process of capsid disassembly of the hepatitis B virus at an atomic level to help develop targeted therapies.

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Novel model developed to resemble aberrant IPF lung epithelium

31 August 2021 | By Anna Begley (Drug Target Review)

A new model that closely resembles aged lung epithelium in idiopathic pulmonary fibrosis has been developed, possibly leading to treatments.

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Genetic treatment reverses age-related memory loss in mice

28 July 2021 | By Anna Begley (Drug Target Review)

Scientists have shown that manipulating the perineuronal nets (PNNs) in the brains of mice led to the reversal of age-related memory loss.

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Recognition of phosphohistidine-containing peptides by antibodies

16 July 2021 | By Dr Rajasree Kalagiri (Salk Institute), Professor Tony Hunter (Salk Institute)

In this article, Dr Rajasree Kalagiri explains research into the use of monoclonal antibodies for the differential recognition of phosphohistidine-containing peptides.

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Microcrystal electron diffraction could advance drug development

14 July 2021 | By Anna Begley (Drug Target Review)

UK researchers have shown how microcrystal electron diffraction (MicroED) could obtain the structures of potential pharmaceuticals.

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Structural changes in SARS-CoV-2 Alpha and Beta variants revealed

28 June 2021 | By Victoria Rees (Drug Target Review)

A study has uncovered previously unknown properties of the Spike protein from the SARS-CoV-2 Alpha and Beta variants.

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Structure of DNA actively involved in genome regulation, study shows

10 May 2021 | By Victoria Rees (Drug Target Review)

Researchers have shown that topoisomerase TOP2A eliminates negative supercoiling, causing an increase in the number of turns of DNA strands and impacting gene expression.

Imaging technique for protein that is cancer drug target

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Structure of PLEKHA7 protein domain imaged, presenting cancer drug target

22 April 2021 | By Victoria Rees (Drug Target Review)

A range of imaging and computational techniques were used by researchers to discover the structure of the PH domain of PLEKHA7.

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Dynamic model of SARS-CoV-2 S protein reveals vaccine targets

7 April 2021 | By Victoria Rees (Drug Target Review)

A model of the SARS-CoV-2 Spike protein surface has uncovered vulnerabilities that researchers say could inform the development of COVID-19 vaccines.

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Revealed structure of enzyme could progress cancer research

5 April 2021 | By Victoria Rees (Drug Target Review)

Researchers have elucidated the 3D structure of the Taspase 1 enzyme, known to be involved in a range of cancers.

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First 3D images of Survival Motor Neuron complex visualised

25 March 2021 | By Victoria Rees (Drug Target Review)

Researchers have imaged the entire Survival Motor Neuron complex using X-ray diffraction analysis, among other techniques.

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Unpredicted binding found between SARS-CoV-2 and hepatitis C drug, telaprevir

24 March 2021 | By Victoria Rees (Drug Target Review)

Insights into the interaction between telaprevir and the SARS-CoV-2 main protease could aid in future COVID-19 drug design, say scientists.

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Conformational equilibria in GPCRs provides clues about activation

23 March 2021 | By Victoria Rees (Drug Target Review)

Having revealed the activation mechanism and functional states of A2AR signalling, a GPCR, researchers say this could aid drug discovery.

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Molecular technique could provide key for SARS-CoV-2 drug discovery

22 March 2021 | By Victoria Rees (Drug Target Review)

Researchers are using a new method to isolate the complex between SARS-CoV-2 and the ACE2 receptor to keep it embedded in the cell membrane.

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Structural biology