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Stem Cells

Stem cells are undifferentiated biological cells that can differentiate into specialised cells and can divide to produce more stem cells.

news

Stem cell therapy with biodegradable scaffold

5 November 2018 | By Drug Target Review

A biodegradable scaffold used to transplant stem cells and deliver drugs, could help in the treatment of brain diseases...

news

Skeletal stem cells de-differentiate to achieve extensive growth

1 November 2018 | By Drug Target Review

Researchers in the U.S. have discovered that skeletal stem cells in the jaws of adult mice de-differentiate when tasked with regenerating large portions of bone and tissue.

news

GFAP gene mutation creates tangles in brain cells – cause of neurological disease

26 October 2018 | By Drug Target Review

A recent study in the U.S. has identified how a mutation in the GFAP gene, which encodes for the GFAP protein, causes the tangles in brain cells associated with Alexander disease and may also impact other neurological diseases.

Integrated fragment-based approach reveals enzymatic inhibitors with potential therapeutic application

webinar

Integrated fragment-based approach reveals enzymatic inhibitors with potential therapeutic application

25 October 2018 | By NanoTemper Technologies

In this webinar, speakers presented results of integrated fragment-based approaches that have led to the discovery of the first ligands of IDO1 that are able to modulate non-catalytic signalling functions of the enzyme...

news

Helping blood cells to regenerate after radiation therapy

24 October 2018 | By Drug Target Review

Researchers at MIT have identified a way to stimulate a particular stem cell in order the hasten the regeneration of red blood cells...

news

Cancer stem cells use normal genes in abnormal ways

15 October 2018 | By Dr Zara Kassam (Drug Target Review)

Researchers have identified that MHC Class I-high, CDK1 high molecules may be at the heart of conditions including melanoma, pancreatic and colon cancers...

news

Umbilical cord stem cells used for early repair of cleft palate

3 October 2018 | By Drug Target Review

Stem cells harvested from the umbilical cord after birth could lead to a therapy to treat cleft lip and palate without the traditional surgery...

news

New technique generates brain stem cells more efficiently

2 October 2018 | By Drug Target Review

Scientists in Ohio have developed a more efficient means of creating brain stem cells, specifically oligodendrocyte progenitor cells, or OPCs, which will help facilitate greater understanding of neurological disorders that result from myelin damage.

news

Oxygen sensitive nanoparticles used for 3D printing of complex tissue-like structures

2 October 2018 | By Drug Target Review

Researchers have implemented oxygen sensitive nanoparticles into a gel material that can be used for 3D printing of complex, biofilm and tissue-like structures...

article

Improved screening of therapeutic candidates using integrated fragment-based approaches

12 September 2018 | By NanoTemper Technologies

An integrated fragment-based approach, which reveals enzymatic inhibitors with potential therapeutic application, is the subject of this webinar.Taking place on 25 October 2018 at 3:00pm, the webinar is supported by NanoTemper Technologies.

article

Expert view: The development of single‑cell genomics with Smart‑seq

12 September 2018 | By Dr François- Xavier Sicot (Takara Bio)

Takara Bio has played a major role in the development of single-cell genomics with the launch of kits such as the automation-ready Smart-seq HT, with a simplified 4-steps protocol. In addition, to meetthe demand for using RNA-seq for degraded clinical samples, we have expanded our offering with a complete sequencing…

Yannick Marrari, Ph.D. Product Manager EMEA Cell Biology, Bio‑Rad

article

Expert view: Generate high‑content information using flow cytometry

11 September 2018 | By Yannick Marrari (Bio-Rad)

Flow cytometry has become a widely used technology in life science research since its development in the 1970s. It is also essential for many biopharmaceutical and biotechnology companies due to its proficiency in identifying biomarkers, finding new inhibitory antibodies, and assessing the efficiency of new pharmacological protocols.

article

Upstream Bioprocessing In-Depth Focus 2018

10 September 2018 | By Drug Target Review

In this In-Depth Focus: upstream cell culture processes for the production of therapeutic proteins, the evolving role of three-dimensional in-vitro cell culture techniques in drug discovery, and human iPSCs-derived functional cells are revolutionising phenotypic drug discovery and development.

article

Expert view: Multiplexed screens in biologics discovery

7 September 2018 | By Thomas D. Duensing (IntelliCyt)

Biologics are the fastest growing class of therapeutics in the biopharmaceutical industry. A key driver for this growth is success with anti-cancer immunotherapeutics such as checkpoint modulation, adoptive cell therapy and bispecific T-cell engagers. While these approaches use different tactics to attack tumours, they often employ monoclonal antibodies to target…

article

Expert view: Large‑scale stem cell expansion and differentiation

6 September 2018 | By Dr. Philipp Nold (Eppendorf)

Stem cell-based technologies lay the basis for pioneering approaches in drug screening, toxicology testing, and regenerative medicine. The constant supply of high cell numbers in consistent quality needs scalable culture systems and standardised process conditions.

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Stem Cells