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Application note: Using SYPRO® Orange to Detect Protein Melting Temps
Investigation of thermal protein stability in high throughput using the application of thermal shift assay using SYPRO ® Orange in 96 well format.
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Screening
Medical screening is a strategy used to identify the possible presence of an as-yet-undiagnosed disease in individuals without signs or symptoms.
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Application note: Detection of Mastitis Pathogens in Raw Milk
Detection of four pathogens of mastitis diseases using qTOWER³ in combination with extraction and detection systems for DNA diagnostics.
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Application note: Automated DNA Extraction and Species Analysis
Combining automated nucleic acid extraction, photometry and qPCR for easy-to-use and highly sensitive species analysis of cheese.
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Application note: Automated Extraction of High Molecular Weight DNA
SmartExtraction significantly simplifies the entire automated workflow of DNA extraction.
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New vaccine protects from widespread, costly infection
A new vaccine against the Staphylococcus aureus infection has proven effective in experiments with mice, with an 80 percent survival rate.
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Application note: Multiplex Fluorescent Western Blot Detection
Challenge: One touch imaging of multiple proteins on the same blot with NIR fluorescent tags. Solution? Automated imaging with the UVP ChemStudio.
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eBook: Simple as a Selfie: One-Button Scientific Imaging
Proper signal visualization, detection, and quantification are paramount to the acquisition of accurate and reproducible data...
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Application note: In Vivo Imaging with GFP
Challenge: Non-invasive imaging of a patient-derived orthotropic mouse model of pancreatic cancer expressing GFP. The solution? In vivo imaging.
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eBook – Getting the Inside Story: In Vivo Imaging
In vivo imaging has been an indispensable and powerful tool in biomedical research, enabling a number of significant breakthrough discoveries.
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Liver-Chip used to study toxicity of drug candidates
Researchers have made a ‘Liver-Chip’ which is able to demonstrate the toxic effects of drug candidates and compounds in human patients.
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Application note: Reliable Single Cell Cloning with Advanced Microfluidic Dispensing
Find out how to accelerate and improve selective single cell cloning with advanced microfluidic dispensing.
webinar
New horizons in small molecule solubility screening
22 October 2019 | By Halo Labs
Aqueous solubility of small molecule compounds is an essential parameter during the hit-to-lead stage of drug discovery as well as lead optimization and formulation. Low solubility can result in misleading ADMET/DMPK analyses if some fraction of a compound precipitates. Watch on-demand to find out more!
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CRISPR RNA-cutting enzyme programmed to kill viruses in human cells
Researchers have developed CRISPR-Cas13 enzyme-based technology that can be programmed to both detect and destroy RNA-based viruses in human cells.
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The challenges of hit-to-lead in drug discovery
A study that identified 12 novel compounds that may prove valuable against new drug targets for leishmaniasis and Chagas disease was not without complication. Here, we discuss the findings but also the challenges the researchers reported in their hit-to-lead study.
