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F50/T50 combination provides artificial ovary prototype
A protein formulation based on fibrin resembles the architecture and rigidity of human ovarian tissue and could be used for ovary transplant...
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Proteomics
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Identification of hits and leads for human African trypanosomiasis
Neglected tropical diseases (NTD) affect more than one billion people and new targets and drugs are needed to tackle these infections. The multi-disciplinary NMTrypI consortium has identified a number of different compound classes which could be effective against these diseases. This article reviews some of these compounds...
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New weakness found in most common childhood malignant brain tumour
A new weakness found in medulloblastoma could lead to more personalised medicine and improved treatment for some patients.
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FUNDC1 protein in cardiac muscle cells linked to heart failure
Reducing a protein found in the mitochondria of cardiac muscle cells initiates cardiac dysfunction and heart failure...
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Pancreatic cancer: specific protein promotes development of pancreatitis and tumours
A study has shown that disruption to cell autophagy is involved in the development of pancreatic cancer.
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Drug Target Review – Issue #4 2017
Issue 4 of Drug Target Review looks at artificial intelligence in drug discovery and features In-Depth Focuses on Screening, Hit to Lead and Informatics.
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New Alzheimer’s animal model more closely mimics human disease
Researchers have found that amyloid-? facilitates the interaction between the plaques and abnormal tau.
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DNA mutations shed in blood predicts response to immunotherapy
Blood sample, or liquid biopsy, can reveal which patients will respond to checkpoint inhibitor-based immunotherapies...
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RT-QuIC testing detects prion protein in the skin of CJD patients
Scientists have detected abnormal prion protein in the skin of patients that have died from Creutzfeldt-Jakob disease...
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Alzheimer’s Tau protein forms toxic complexes with cell membranes
Researchers identify the sequence and structural factors that drive Tau interaction with membranes...
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AFM-CRISPR technique used to map DNA mutations
Nanomapping technology may transform the way disease-causing genetic mutations are diagnosed and discovered...
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Reducing TIA1 improves nerve cell health in Alzheimer’s disease
Researchers have described a unique model for the biology of Alzheimer's disease which may lead to an entirely novel approach for treating the disease...
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CXCL5 protein may protect against coronary artery disease
Researchers have identified a possible genetic basis for coronary artery disease...
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Proteome of the human heart mapped for the first time
Researchers have compiled an atlas of the heart to identify differences between healthy and diseased cells...
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SORLA protein protects against Alzheimer’s disease
Researchers have identified a new protective function for a brain protein genetically linked to Alzheimer's...
