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Engineered stem cells shown to target breast cancer that metastasises to brain
A team have shown that a tumour-suppressing and killing molecule delivered to the brain by stem cells has been successful in mice.
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Oncology
Oncology is a branch of medicine that deals with the prevention, diagnosis and treatment of cancer.
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Researchers use viruses as vectors to deliver cancer vaccines
A team has used two viruses to administer specific tumour components in mice with cancer to stimulate their immune system.
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Blocking Treg pathway sensitises mice to immunotherapy
Researchers have shown that inhibiting Treg activation in tumours can provide effective immune responses without autoimmune toxicity.
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Researchers find MAPK4 enzyme presents target for prostate cancer
Research has shown that MAPK4 activates two molecules in cellular signalling pathways involved in prostate cancer growth.
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NOX5: a novel target for sensitising melanoma to therapies
Vito Quaranta, professor of biochemistry and pharmacology, discusses how cancerous cells adopting novel mechanisms of energy production could be sensitised to existing therapies with a focus on melanoma.
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NAD depletion by IFN sensitises pancreatic cancer to NAMPT inhibition, study shows
High IFN signalling in pancreatic tumours are sensitive to NAMPT inhibitors which block a pathway in NAD synthesis, presenting a drug target.
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LEAP proton therapy could target cancer cells that resist treatment
A proton therapy that targets cancer cells which are resistant to treatment has shown success, sparing surrounding healthy cells.
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New drug combination could combat Diffuse Intrinsic Pontine Glioma
The drug combination of difluoromethylornithine and AMXT 1501 has shown success against Diffuse Intrinsic Pontine Glioma in animal models.
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Inhibiting enzyme could provide strategy to halt glioblastoma growth
A study has shown that inhibiting the enzyme PRMT5 can suppress the growth of glioblastoma cells in pre-clinical studies.
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CRISPR used to model acute myeloid leukaemia progression
CRISPR-Cas9 and stem cell technologies have been used to create a cellular model of acute myeloid leukaemia, revealing therapeutic targets.
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Platform reveals insights into cancer genomics and personalised medicine
Researchers have developed a personalised medicine platform that could advance genomic medicine research for cancer.
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Single cell analysis reveals sympathoblasts as target to treat neuroblastoma
Researchers have discovered that all childhood neuroblastomas come from sympathoblasts, making them a drug target to treat the condition.
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Could metabo-oncology be the treatment modality of the future?
Jim Shanahan from SynDevRx explains why metabo-oncology treatment modalities could be the answer to a rise in metabolic disorders and cancers.
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Tissue damage and genetic mutations interact to drive pancreatic cancer, finds study
New research shows tissue damage to cells carrying KRAS mutations induces epigenetic changes that promote pancreatic cancer.
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Preventing stem cells from transforming into pre-leukaemia stem cells
Researchers have discovered that two enzymes called APOBEC3C and ADAR1 work together to fuel the transition from pre-cancer stem cells to cancer stem cells in leukaemia.
