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Drug candidate stops tumour growth with little toxicity in mice
A star-shaped molecule along with a modified platinum drug have demonstrated success at combatting tumours with few toxic effects in mice.
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Oncology
Oncology is a branch of medicine that deals with the prevention, diagnosis and treatment of cancer.
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Ru-Pt conjugate drug could be the future for cancer therapies
Researchers combined cisplatin, an enhancer and a photodynamic therapy (PDT) drug into a single conjugate that had 10 times the efficacy in treating treatment resistant cancer cells.
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Copper ions could be key to blocking cancer metastasis
Researchers have identified that copper ions and their protein transporters, such as Atox1, are key to cancer cell movement and could be targeted by therapies.
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Increasing ion channel function in cancer T cells could be new immunotherapy
Researchers have found that there is less calmodulin binding to ion channels in the T cells from cancer patients, presenting a new immunotherapeutic target.
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Researchers develop imaging technique to study 3D-printed brain tumours
A new method has been created by researchers to 3D bioprint tumours and image glioblastomas for the study of therapeutics.
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CAR T-cell receptors based on scorpion venom show efficacy in mice
Combining the chlorotoxin peptide with conventional CAR structures, researchers have created a new CAR T cell therapy that has successfully combatted glioblastomas in mice.
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T-cell regulator SLAMF6 may be hindering immunotherapy success
A new study conducted in Israel suggests that T cells’ ability to destroy skin cancer increases in the absence of T-cell regulators called SLAMF6.
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Researchers find drug improves cancer immunotherapy in mice
A study has shown that in mice, the GKT137831 drug makes tumours more sensitive to immunotherapy, so could be used to improve cancer treatments.
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Stainless imaging developed by adding infrared to standard microscopes
A new method to image cancerous tissues has been created by researchers who have paired infrared measurements with high-resolution optical images.
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Infrared light used to improve photodynamic therapy in model tumours
Researchers have developed a compound that can be activated with infrared light to kill cancer cells in model tumours, advancing the possibilities of photodynamic therapy.
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Lung cells found to support hibernating breast cancer cells in mice, revealing target
A study has shown that breast cancer cells are protected by healthy cells in the lungs of mice, allowing them to hibernate before growing into tumours.
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ILC2s sensitise pancreatic tumours to PD-1 checkpoint inhibitors in mice
Scientists identify innate lymphoid cells (ILCs) as possible targets for immunotherapies as their activation makes murine pancreatic tumours sensitive to PD-1 checkpoint inhibitors.
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Using blue light to control CAR T cells and destroy tumours
Researchers have created a method to activate CAR T cells with blue LED light to successfully combat solid tumours in mice.
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Receptor protein activity could prevent neuropathy for chemotherapy patients
A team of researchers in Singapore has studied the activity of a receptor protein to identify whether it’s a key player in the development of neuropathy for patients undergoing chemotherapy.
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WDR74 protein identified as lung cancer and melanoma therapeutic target
Researchers have revealed that the WDR74 protein plays a key role in lung cancer and melanoma, including metastasis, indicating it may be a potential drug target.
