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Neurosciences

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Team sheds light on the co-ordination of neural stem cell activation

12 April 2021 | By Victoria Rees (Drug Target Review)

Scientists have visualised the spatial and temporal distribution of neural stem cell activation in zebrafish models.

news

Team reveals miR-29 as regulator of processes for normal brain maturation

7 April 2021 | By Victoria Rees (Drug Target Review)

Researchers have shown that miR-29 can control brain maturation in mammals, presenting a target for autism, epilepsy and other conditions.

news

New drug target identified to potentially fight neuroblastoma

29 March 2021 | By Victoria Rees (Drug Target Review)

Researchers have revealed that the protein ALYREF promotes the effects of the neuroblastoma gene, MYCN, making it a target.

news

Polymerised oestrogen provides neuroprotection in pre-clinical study

23 March 2021 | By Victoria Rees (Drug Target Review)

The polymerised form of oestrogen has shown success in mice at preventing further damage to the spinal cord after injury.

news

‘Zinc finger’ gene therapy could help to treat Alzheimer’s disease

23 March 2021 | By Victoria Rees (Drug Target Review)

Promising results have been shown in an animal model of Alzheimer's disease treated with zinc finger protein transcription factors.

news

Cannabinoids could reduce essential tremors in patients

22 March 2021 | By Victoria Rees (Drug Target Review)

A synthetic cannabinoid has shown promise as a treatment for involuntary tremors by activating astrocytes in mouse models.

news

Rhesus macaque model of Alzheimer’s disease developed

19 March 2021 | By Victoria Rees (Drug Target Review)

Scientists have developed a model of the early stages of Alzheimer's disease in rhesus macaques to better test new treatments.

news

Nano-micelles used in CRISPR genome editing of mouse brains

12 March 2021 | By Victoria Rees (Drug Target Review)

Researchers have reported that nano-micelles can be used to efficiently deliver CRISPR-Cas9 to edit genes in the brains of mice.

article

Developing bioenergetic nanocatalysts, a novel approach to treat neurodegeneration

8 March 2021 | By Hannah Balfour (Drug Target Review)

Mark Mortenson, CSO of Clene Nanomedicine, discusses the use of proprietary gold nanocrystals as catalysts to prevent the progression of, and act as a treatment for, neurodegenerative disease.

news

AI-based method used to screen for Alzheimer’s disease drugs

5 March 2021 | By Victoria Rees (Drug Target Review)

Researchers have used artificial intelligence to screen 80 FDA-approved drugs and reveal which could be used as Alzheimer's treatments.

news

Structure of protein that triggers neurodegeneration isolated and analysed

4 March 2021 | By Victoria Rees (Drug Target Review)

Using X-ray crystallography and cryo-electron microscopy, researchers have elucidated the structure of the SARM1 protein, a target for neurodegeneration.

news

New drug shows potential as prophylactic for Alzheimer’s disease

3 March 2021 | By Victoria Rees (Drug Target Review)

In pre-clinical studies, a novel treatment decreased plaque formation, meaning it could be used to prevent Alzheimer's disease.

news

Hymecromone can suppress neuroinflammation in astrocytes, study shows

1 March 2021 | By Victoria Rees (Drug Target Review)

Researchers have found that the spasmolytic drug hymecromone can suppress astrocyte inflammatory responses, meaning it could be used to combat Alzheimer's disease.

news

Neuron damage from ALS reversed with new compound

24 February 2021 | By Victoria Rees (Drug Target Review)

Scientists have developed a compound that stops the degeneration of upper motor neurons, a contributor to amyotrophic lateral sclerosis (ALS).

news

Study shows that FOXO3 gene protects brain stem cells

22 February 2021 | By Victoria Rees (Drug Target Review)

A version of the FOXO3 gene can protect brain stem cells from stress during ageing, according to a new study.

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Neurosciences