In Vivo

Diabetes-related proteins examined for the first time at high resolution

27 January 2020 | By Rachael Harper (Drug Target Review)

A key receptor has been examined for the first time at high resolution which could lead to better treatments for conditions such as type 2 diabetes.

Getting precise: how humanised models aid in biologics drug discovery

17 December 2019 | By Paul Volden (Taconic Biosciences)

Humanised immune system (HIS) models have enabled numerous in vivo evaluations of immuno-modulating biologic drugs and ongoing improvements continue to extend their utility. Paul Volden explores the application of HIS models in precision and personalised medicine with a focus on biologics, including how HIS models are used, why they are…

eBook: Simple as a Selfie: One-Button Scientific Imaging

13 November 2019 | By Analytik Jena

Proper signal visualization, detection, and quantification are paramount to the acquisition of accurate and reproducible data...

Application note: In Vivo Imaging with GFP

12 November 2019 | By Analytik Jena

Challenge: Non-invasive imaging of a patient-derived orthotropic mouse model of pancreatic cancer expressing GFP. The solution? In vivo imaging.

eBook – Getting the Inside Story: In Vivo Imaging

12 November 2019 | By Analytik Jena

In vivo imaging has been an indispensable and powerful tool in biomedical research, enabling a number of significant breakthrough discoveries.

Analytik Jena

Clues discovered for why MYH9 gene mutations cause human disorders

29 October 2019 | By Rachael Harper (Drug Target Review)

A new study has demonstrated for the first time that mutations that affect myosin motor activity result in slower cell movements in vivo.

Molecule discovered that regulates development of tumours

9 September 2019 | By Rachael Harper (Drug Target Review)

Researchers discover that a non-coding region of the genome originates a key molecule for the proliferation of cancerous tumours.

Experimental compound slows blood cancer growth

23 July 2019 | By Victoria Rees (Drug Target Review)

Researchers have identified a protein that plays a role in promoting blood cancer and have successfully used a novel compound to inhibit it, reducing tumour growth.

Case study: Shipping media for fresh tissue

2 July 2019 | By BioIVT

For biomarker discovery efforts, primary cell assays, and patient-derived xenograft work, among others, access to fresh human surgical tissue is an essential component in obtaining reliable results.

New model found to improve drug development in pre-clinical trials

20 June 2019 | By Drug Target Review

Researchers have successfully created a multi-organ in vitro model to test toxicity and efficacy of drugs.

Experimental treatment for sickle cell disease success

20 June 2019 | By Victoria Rees (Drug Target Review)

Researchers announce positive pre-clinical results for two sickle cell disease treatment strategies.

Screening In-Depth Focus 2019

7 June 2019 | By Drug Target Review

This in-depth focus discusses screening and the uses of phenotypic profiling in drug discovery. Also examined is the role that CRISPR/Cas9 gene editing and native mass spectrometry play.

The importance of characterising chemical starting points of drugs using appropriate in vitro ADME-toxicity assays

21 March 2019 | By Massimiliano Runfola - University of Pisa - Italy, Sheraz Gul - Fraunhofer IME - Germany

Over the past 30 years, one strategy the pharmaceutical industry has adopted in the drug discovery process has been to “fail early, fail often”.1,2 As most molecules in the early stages of drug discovery will have sub-optimal characteristics, significant modification is necessary to improve their properties.

Nuclear tracers help assess new drugs for neurodegenerative diseases

21 January 2019 | By Dr Zara Kassam (Drug Target Review)

New nuclear medicine tracers could help medical researchers find a cure for Alzheimer's and other neurodegenerative diseases.