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Analogue of psychedelic ibogaine reverses effects of stress in mice
Tabernanthalog (TBG), similar to the psychedelic drug ibogaine, corrected stress-induced behavioural deficits in mice.
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Researchers synthesise potential anticancer compounds
Scientists have developed six new derivatives of 4-chloro-1,2-dithiol-3-thione, which have all demonstrated anticancer effects in pre-clinical studies.
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Nanoparticle flu vaccine shows promise at protecting mice
Using nanoparticle liposomes, researchers have developed an experimental flu vaccine that has shown success in pre-clinical studies.
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Potential COVID-19 antiviral formulated with siRNA-nanoparticles
Scientists have created an antiviral therapy using lipid nanoparticles that deliver siRNA to the lungs to treat COVID-19 in mice.
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Novel inhibitor blocks myeloma cancer cell growth in mouse model
Having identified the histone demethylase KDM5A as a multiple myeloma target, researchers developed a KDM5 inhibitor to treat the cancer.
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Asthma vaccine shows success in pre-clinical studies
A new conjugate vaccine has shown promise at protecting mice against the effects of cytokines associated with asthma.
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New mouse model could be used to develop better HIV treatments
A new pre-clinical mouse model could enable the study of HIV infection and the testing of cell therapies against the virus.
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Brochure: Diabetes Solutions
Solutions to aid understanding of cellular and molecular pathways in diabetes and translate these findings into prevention and treatment strategies.
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New vaccine protects against COVID-19 and variants in pre-clinical studies
A new vaccine has shown promise at protecting monkeys and mice from COVID-19, its variants and other coronaviruses.
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Researchers use exosomes to develop potential salmonella vaccine
Exosomes containing salmonella antigens were administered to the mice, enabling the models to develop antibodies against the bacteria.
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Stem cell-based vaccine protects mice against pancreatic cancer
Researchers have developed a vaccine using stem cells that protected mice injected with pancreatic cancer cells from developing tumours.
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Gene therapy in Alzheimer’s mouse model preserves learning and memory
A new gene therapy that introduced SynCav1 to the brains of Alzheimer's mouse models was shown to preserve neuronal and synaptic plasticity.
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Hepatitis C drugs shown to boost remdesivir’s activity against SARS-CoV-2
Four hepatitis C drugs have demonstrated promise as boosters to increase the efficacy of remdesivir against SARS-CoV-2 by as much as tenfold.
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Nanobody cocktail shown to block SARS-CoV-2 infection in mouse models
Researchers have used cryo-EM to show that a new nanobody cocktail can bind to the S protein of SARS-CoV-2, neutralising the coronavirus.
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Inhibiting METTL3 enzyme combats acute myeloid leukaemia in mice
Scientists have developed a drug called STM2457 which inhibits a key enzyme involved in acute myeloid leukaemia.
