news
Pro72Arg gene variant increases tumour cell metabolism
Scientists have found a mechanism through which mutant p53 enhances metastasis by controlling tumour metabolism...
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In Vitro
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Charles River Laboratories announces new tumour model compendium
The Compendium provides scientists an online resource to help design efficient in vitro and in vivo oncology research studies.
webinar
Streamlining drug discovery assays for cancer and cardiovascular disease
1 February 2018 | By PerkinElmer
This webinar discussed a screening assay that recapitulates the activation of ER stress sensor IRE1 and an assay to quantify cell migration phenotypes, as applied to cardiovascular target validation and drug discovery.
news
Sirt2 enzyme identified as therapeutic target for diabetes
Researchers have identified the sirtuin enzyme as a key player in regulating hepatic glucokinase through modifying GKRP, suggesting a potential therapeutic target for type 2 diabetes...
news
Blood-vessel-on-a-chip provides insight into new anti-inflammatory drug candidate
Researchers have discovered that synthetic APC-mimicking molecules provide anti-inflammatory and anti-thrombotic protection to endothelial cells without interfering with blood clotting...
article
Expert view: Conquering late stage failures with advanced hit-to-lead techniques
Failing early in drug discovery is the primary driving force for new techniques in the hit-to-lead phase.
article
Identification of hits and leads for human African trypanosomiasis
Neglected tropical diseases (NTD) affect more than one billion people and new targets and drugs are needed to tackle these infections. The multi-disciplinary NMTrypI consortium has identified a number of different compound classes which could be effective against these diseases. This article reviews some of these compounds...
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Charles River adds ERS License to CRISPR/Cas9 service offering
Charles River Laboratories International, Inc. announced the expansion of its CRISPR/Cas9 service offering with the addition of a license from ERS Genomics Limited.
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Stem cell-derived intestine model mimics innate immune responses
A stem cell-derived in vitro model displays key small intestine characteristics including innate immune responses.
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Charles River announces expansion of in vitro oncology services
Partnership with InSphero provides additional 3D solutions...
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Phenogenetic map created for stem cell models of neurological diseases
Researchers have performed meta-analysis of neurological and neurodegenerative diseases and created an atlas of how cell characteristics are linked to their genotype...
webinar
Integrated drug discovery panel – your questions answered!
28 September 2017 | By Charles River
During this peer panel discussion, team members from Charles River discussed their views and strategies on Drug Discovery...
news
Exosomes identified as the missing link to insulin resistance
Researchers have identified exosomes as the missing link in diabetes...
article
Expert view: Innovations in 3D
Physiologically relevant models to evaluate the effects of drug candidates early in the drug discovery and development process are becoming increasingly important to develop. Various 3D cell/tissue models have emerged offering relevant environment for ex vivo assays, but significant progress is required to streamline and automate the end-to-end workflow. Several…
news
Polyphor achieves first milestone from Wellcome for antibiotic development
Polyphor achieves first milestone from Wellcome Trust for the development of antibiotics against Gram-negative multi drug - resistant pathogens...
