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In Vitro

Cell culture plates with orange growth media and a pipette above

news

Cell line development services market to grow at 13.3 percent

12 November 2020 | By Hannah Balfour (Drug Target Review)

Reports suggest the market growth is driven by advances in biotechnology and its applications, as well as COVID-19 research.

robotic hand pipetting from petri dish of organoids next to a clock - idea of automation speeding up organoid development [Credit: Daria Sokol/MIPT Press Office].

news

Researchers accelerate organoid development and selection using algorithm

11 November 2020 | By Hannah Balfour (Drug Target Review)

The semi-automated process enabled researchers to make retinal organoid production and selection nearly four times faster.

Close up graphic of SARS-CoV-2 particle in grey, with red spike proteins, binding to a yellow cell surface ACE2 receptor

news

Researchers develop ACE2 decoy to neutralise SARS-CoV-2

10 November 2020 | By Hannah Balfour (Drug Target Review)

Using their de novo protein design strategy, researchers engineered human angiotensin converting enzyme 2 (hACE2) protein decoys that can protect cells from SARS-CoV-2 infection.

Three-dimensional (3D) illustration of amyloid beta plaques (brown mesh-like shapes) forming between neurons and disrupting their function. Amyloid plaques are a hallmark of Alzheimer’s Disease.

news

Developing drugs for disordered proteins

6 November 2020 | By Hannah Balfour (Drug Target Review)

Scientists have developed a drug-like molecule to target amyloid-beta, a disordered protein implicated in Alzheimer's disease that has been considered undruggable.

woman scratching the back of her leg while walking on grass - idea of allergic reaction itching

news

Researchers reveal how allergens may trigger itching

2 November 2020 | By Hannah Balfour (Drug Target Review)

Certain sensory neurons and Substance P are potential drug targets for the development of novel allergy preventions or treatments, according to scientists.

SARS-CoV-2 particles infecting a human cell

news

Lysosomes key to coronavirus shedding, finds study

29 October 2020 | By Hannah Balfour (Drug Target Review)

Scientists reveal that coronaviruses de-activate lysosomes before using them to exit infected cells and spread through the body.

heart on an abstract blue scientific background

news

Organs-on-a-chip model for breast cancer drug cardiac toxicity testing

27 October 2020 | By Hannah Balfour (Drug Target Review)

The newly developed chip includes heart and breast cancer tissues and could be used to predict the cardiac toxicity of chemotherapeutic drugs.

SARS-CoV-2 particles entering human cells

news

SARS-CoV-2 also uses neuropilin-1 to infect human cells

21 October 2020 | By Hannah Balfour (Drug Target Review)

Researchers reveal that SARS-CoV-2 is more infectious than SARS-CoV because it can use both ACE2 and neuropilin-1 to infect cells.

news

Researchers uncover drivers of memory B cell formation

13 October 2020 | By Hannah Balfour (Drug Target Review)

The team demonstrated that expression of Bach2 protein and reduced mTORC1 activity is necessary for germinal B cells to become memory B cells.

Futuristic image - DNA stand with scissors about to cut it - idea of CRISPR gene editing

news

CRISPR used to eliminate cancers caused by fusion genes

9 October 2020 | By Hannah Balfour (Drug Target Review)

Using CRISPR to cut out fusion genes, scientists were able to specifically induce cancer cell death in murine models of sarcoma and leukaemia.

person's gloved hand holding a 96 well cell culture plate overlaid on cartoon cells

news

Small molecules to reduce cellular stress identified by HTS

6 October 2020 | By Hannah Balfour (Drug Target Review)

Scientists used high throughput screening (HTS) to identify molecules that protect against cellular stress in murine skin cells.

red viruses pouring out of pink human cell

news

Approved MS medication inhibits SARS-CoV-2 replication in vitro

5 October 2020 | By Hannah Balfour (Drug Target Review)

Dimethyl fumarate (DMF), a multiple sclerosis (MS) drug, inhibited SARS-CoV-2 replication and the hyper-inflammatory immune response associated with COVID-19.

Ovarian cancer cells forming a cancer spheroid as they grow within the peptide-protein co-assembling material [Credit: Alvaro Mata].

news

Novel tumour spheroids could improve ovarian cancer treatments

5 October 2020 | By Hannah Balfour (Drug Target Review)

Researchers have developed a new self-assembling three-dimensional (3D) ovarian cancer tumour model to recreate the in vitro disease more accurately.

colourful SARS-CoV-2 particles surrounding a body shape with the lungs drawn in red

news

The NF-κB pathway drives fatal inflammation in COVID-19, say scientists

2 October 2020 | By Hannah Balfour (Drug Target Review)

Researchers found that the SARS-CoV-2 infection activates the NF-κB pathway, driving unchecked inflammation that contributes to total organ failure in COVID-19 patients.

Glioblastoma Multiforme (GBM) cells in culture [Credit: Dr Jin-Min Nam].

news

Identifying radioresistance drivers in glioblastoma multiforme

1 October 2020 | By Hannah Balfour (Drug Target Review)

According to researchers, Rab27b and epiregulin contribute to the development of radioresistance and could be targeted to improve glioblastoma patient survival.

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In Vitro