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Application note: Analyte quarterly Vol 1
Your comprehensive guide to multiplex and single protein detection...
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Immunooncology
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The loss of CDK12 pinpoints to a new sub-type of prostate cancer
Tumours with alterations in the CDK12 gene were more responsive to immunotherapy, suggesting precision medicine approach...
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Streamlining drug discovery assays for cancer and cardiovascular disease
For lead optimisation, target-based assays are still the most affordable means of rapidly performing fast iterations and remain core to screening. However, the desire for biological relevance is driving ongoing growth in cell-based assays.
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Transforming translational research: CANscriptTM – a better predictive model for oncology
This webinar focused on a recent study evaluating a cohort of head and neck squamous cell carcinoma (HNSCC) patient tumours treated with anti-PD1 using CANscript™.
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Gut microbiome can control anti-tumour immune function in liver
Scientists have found a connection between bacteria in the gut and antitumor immune responses in the liver...
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Immune processes offer insights into triple-negative breast cancer
Researchers have discovered the process that allows immune suppressor cells to develop, suggesting a potential new way to bolster immunotherapy treatment...
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New insights into the origins of mutations in cancer
Scientists use data from human cancers and C. elegans to understand mutational causes of cancer...
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Lymphocytes armed to kill: how customised cell engineering advances immunotherapy
The immune system is now regarded as a powerful weapon in the war against cancer, and in the current era immune cells have become ‘living drugs’. This review article considers some of the key advances in immuno-oncology...
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Researchers identify compound to prevent breast cancer cells from activating in brain
Researchers have used computer modelling to find an existing investigational drug compound for leukaemia patients to treat triple negative breast cancer...
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Expert view: Addressing the big challenges in cell-based assays
As the drug discovery industry takes on the complex disease states that plague our world, the need for more relevant and timely answers from cell-based assays has become a major challenge.
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High throughput flow cytometry for multifactorial evaluation of novel therapeutic candidates using an innovative in vitro immunooncology screening platform
This recent webinar focused on the role of IntelliCyt’s iQue Screener PLUS platform as a high throughput suspension cell screening platform to facilitate simultaneous assessment of multiple parameters, while using minimal sample volumes.
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Preventing exhaustion in immune cells boosts immunotherapy in mice
Research shows that preventing or reversing ‘T-cell exhaustion’ with targeted therapies could enhance the effects of immunotherapy.
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Charles River Laboratories announces new tumour model compendium
The Compendium provides scientists an online resource to help design efficient in vitro and in vivo oncology research studies.
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Local environment plays key role in breast cancer progression
While studying the complex correlation between tissue stiffness and breast cancer development, researchers found that cancer cells tend to become more aggressive when the surrounding tissue stiffens...
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Immune signature predicts asthma susceptibility
Researchers have identified a subset of T cells, whose frequency serves as early childhood immune signature that predicts the risk of developing asthma later on.
