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Immunooncology

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New class of CAR T cells combat previously “untargetable” cancer drivers

4 November 2021 | By Anna Begley (Drug Target Review)

The peptide-centric chimeric antigen receptors killed neuroblastoma cells in mice and could potentially expand the pool of immunotherapeutic targets.

Immune cell attacking cancer tumour, immunotherapy concept

news

Experimental drug boosts immunotherapy efficacy for pancreatic cancer

4 November 2021 | By Anna Begley (Drug Target Review)

An experimental drug enhanced the benefit of immunotherapy, reducing and in some cases eliminating pancreatic cancer in mice.

podcast

Episode 3 – Cell & gene therapy with Dr Sam Wadsworth, Ultragenyx Pharmaceutical & Dr Eric Ostertag, Poseida Therapeutics

1 November 2021 | By Drug Target Review

Tune in to this podcast to learn about AAV vectors for gene therapy delivery and engineering CAR T cells against solid tumours.

T cell lymphocyte with receptors to kill cancer cell in cancer i

news

Raman spectroscopy used to determine immunotherapy effectiveness

28 October 2021 | By Anna Begley (Drug Target Review)

Researchers used Raman spectroscopy to monitor immunotherapy response in mice, potentially improving cancer treatments in the future.

video

Engineering better CAR T cells with Professor Ann Ager, Cardiff University

27 October 2021 | By Drug Target Review

Watch this exclusive interview with Professor Ann Ager, Cardiff University, to discover how CAR T cells could be targeted against solid tumours.

news

Medicenna’s MDNA11 a promising alternative to checkpoint inhibitors

19 October 2021 | By Anna Begley (Drug Target Review)

Medicenna's IL-2 super-agonist, MDNA11, successfully induced antitumour cells in animal models, a pre-clinical study has revealed.

news

Scientists uncover answer to colorectal cancer immunotherapy resistance

13 October 2021 | By Anna Begley (Drug Target Review)

Boosting dendritic cells prevented immunotherapy resistance in mouse models, suggesting a new approach to colorectal cancer therapies.

Yellow antidepressant pills with smiley faces drawn on

news

Antidepressants inhibit growth of pancreatic and colon cancers in mice

29 September 2021 | By Anna Begley (Drug Target Review)

Scientists have discovered that approved antidepressant drugs cause immune cells to recognise and eliminate tumour cells in mouse models.

news

“Ultrasensitive” HPV detection paves way for precision treatment

28 September 2021 | By Anna Begley (Drug Target Review)

A new study sequenced tumour DNA for the “ultrasensitive” detection of HPV, further honing precision treatment of the illness.

news

New AI method could aid in development of T cell-based cancer therapies

24 September 2021 | By Anna Begley (Drug Target Review)

An artificial intelligence technique can identify which neoantigens are recognised by the immune system, possibly improving cancer prognosis and treatment.

news

Club cell factors may reverse immune suppression in tumours

21 September 2021 | By Anna Begley (Drug Target Review)

New research has revealed that club cells secret anti-immunosuppressive factors in tumours, potentially revolutionising cancer therapies.

news

Controlling PTEN gene could combat paediatric rhabdomyosarcoma

20 September 2021 | By Anna Begley (Drug Target Review)

The decreased expression of PTEN in mouse models was found to make rhabdomyosarcoma tumours more aggressive, highlighting new treatment approaches.

whitepaper

Cell & Gene Therapy Advancements Whitepaper

16 September 2021 | By Drug Target Review

Download this whitepaper to discover the latest research and developments in cell and gene therapies via exclusive articles and interviews.

news

Novel tool can estimate number of T cells in cancer tumours

10 September 2021 | By Anna Begley (Drug Target Review)

Researchers have developed a new method that can rapidly count the number of T cells in a tumour, helping to predict patient response to therapies.

news

STING-activating drugs could customise cancer treatments

9 September 2021 | By Anna Begley (Drug Target Review)

An imaging technique identified emerging drugs that activate the STING protein to alter metabolic pathway activity in cancer cells.

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Immunooncology