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Gene therapy bolsters Parkinson’s drug benefits in pre-clinical study
The gene therapy restored the ability of neurons to convert levodopa to dopamine and may help develop therapies to slow disease progression.
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Hormones
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Eczema may stem from poorly regulated sex hormones, study finds
A breaking discovery has revealed the gene HSD3B1 that regulates the production of sex hormones is linked to atopic dermatitis (AD).
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TREM2 regulation to prevent neurodegeneration is possible, study shows
Scientists used a synthetic thyroid hormone in mice to regulate the TREM2 gene implicated in diseases such as Alzheimer’s and Parkinson’s.
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Obesity could be treated by targeting mitochondrial defect, study finds
Scientists have discovered a new pharmacological approach to reduce the mitochondrial dysfunction that promotes diet-induced obesity in mice.
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Synthetic “switch” is a pivotal step for smart insulin therapy
A novel synthetic “switch” has been developed that could hold the key to revolutionary smart insulin therapy for diabetic patients.
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MIS hormone shown to suppress ovarian follicle development
Researchers have shown how the MIS hormone can prevent ovulation in females, making it a potential new form of contraception.
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Melatonin could act as barrier against SARS-CoV-2 infection
Researchers have suggested using melatonin in a nasal spray to create a protective barrier against SARS-CoV-2 in pre-symptomatic patients.
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Targeting PEG2 reverses age-related cognitive decline in mice
The discovery of an inflammatory pathway promoting brain ageing and cognitive decline could lead to new treatments for age-related conditions.
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Activating androgen signalling has potent anti-breast cancer effects
Researchers show selectively activating androgen receptors could be an effective treatment for oestrogen receptor positive breast cancers.
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Experimental formulation could be future for fast-acting insulin
The novel formulation hit peak activity at nine minutes, less than half the time taken for a commercially available formulation.
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Could novel sex-linked targets provide an autoimmunity therapy?
Recent research into why autoimmune disorders affect women four times more frequently than men has revealed several novel therapeutic targets that may lead to the development of future treatments.
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Islet protective factor GDF15 reduces development of type 1 diabetes in mice
Researchers have discovered that type 1 diabetes patients have low levels of growth differentiation factor 15 (GDF15) in their pancreatic β cells, unlocking a potential alternative to life-long type 1 diabetes disease management.
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Optogenetics used to control diabetes without medication
Scientists in the US have successfully controlled glucose levels in diabetic mouse models without the need for medication.
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Role of gut microbiota studied in pregnant women with lupus
New research findings suggest that gut microbiota may regulate lupus flares in pregnant women, presenting a therapeutic target.
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Hunger hormones offer promising avenue for addiction treatment
Hormones that signal the body's state of hunger and fullness could be the key to new treatments for drug and alcohol addiction...
