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Histones

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Scientists reveal that glioblastoma shows dependency on biotin distribution

15 September 2021 | By Anna Begley (Drug Target Review)

Researchers discovered that glioblastoma cells rely on biotin distribution for growth, leading to possible future drug combinations.

news

Novel inhibitor blocks myeloma cancer cell growth in mouse model

18 May 2021 | By Victoria Rees (Drug Target Review)

Having identified the histone demethylase KDM5A as a multiple myeloma target, researchers developed a KDM5 inhibitor to treat the cancer.

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Researchers develop novel way to identify new cancer drugs

26 January 2021 | By Victoria Rees (Drug Target Review)

A team has developed a new way to discover peptide therapeutics that inhibit HDAC enzymes and are effective against cancer.

stand of DNA behing a side on view of the human head with the brain highlighted in red

news

Epigenetic marks could be the target of future Alzheimer’s therapies

2 October 2020 | By Hannah Balfour (Drug Target Review)

New findings suggest that late-onset Alzheimer's Disease (AD) is driven by epigenetic changes in the brain.

news

Novel small molecules inhibit cancer-associated enzymes in cells

1 September 2020 | By Victoria Rees (Drug Target Review)

A drug-like compound that can inhibit a key family of enzymes associated with several types of cancer has been developed and tested successfully in cells.

news

Novel microfluidic and sequencing method enables epigenetic studies

19 May 2020 | By Victoria Rees (Drug Target Review)

A new microfluidic technology has been developed which can profile histone modifications with as few as 100 cells per assay.

structural image of histones, as a single white mass, wrapped in a strand of DNA

news

Structure of commonly mutated histone chaperone revealed by new study

10 March 2020 | By Hannah Balfour (Drug Target Review)

Researchers have shown how ATAD2, a histone chaperone protein, may load histones on to DNA in order to create the chromatin structure.

news

Histones revealed by study as critical for cell identity

31 October 2019 | By Victoria Rees (Drug Target Review)

Researchers have shown that histones are vital in silencing genes and that their position is inherited in new cells, providing insight into how cancer cells can become resistant to therapy.

news

Frizzled receptors could be drug targets for treating major diseases

5 December 2018 | By Iqra Farooq (Drug Target Review)

Frizzled receptors, from the GPCR family, could soon be a target to treat numerous diseases such as cancer, fibrosis and CVD...

news

Researchers identify cause of heart damage in sepsis patients

9 July 2015 | By Victoria White

Researchers at the University of Liverpool's Institute of Infection and Global Health have discovered a common cause of heart damage in patients with sepsis...

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Histones