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High Throughput Screening (HTS)

Assessing compound activity to accelerate drug discovery

22 June 2021 | By Victoria Rees (Drug Target Review)

In this article, Drug Target Review’s Victoria Rees explores a new screening platform that assesses the biological activity of molecules to identify potential drugs. Using their new technique, researchers from the US National Institutes of Health (NIH) identified potential COVID-19 therapeutics.

article

Why some screening hits are a PAIN

22 June 2021 | By Dr Matthew Lloyd (University of Bath)

A major challenge during high-throughput and fragment screening is the potential for identifying ‘frequent hitters’ – compounds that affect unrelated targets. Matthew Lloyd from the University of Bath explains why these hits can arise during drug discovery and how machine learning could be the answer to identifying these compounds.

article

Drug Target Review Screening ebook 2021

18 June 2021 | By Drug Target Review

This ebook has articles on the use of screening to identify COVID-19 drugs and how assessing compound activity could accelerate drug discovery.

news

High-throughput screening protocol created to discover SHP2 inhibitors

18 June 2021 | By Victoria Rees (Drug Target Review)

Researchers have developed a cross-validation high-throughput screening method to accelerate the identification of SHP2 inhibitors.

news

Screening identifies existing drugs as potential COVID-19 therapies

8 June 2021 | By Victoria Rees (Drug Target Review)

Scientists have found four clinically approved drugs and nine compounds with the potential to be repurposed as therapeutics for COVID-19.

Screening reveals antivirals for henipavirus

news

High-throughput screening platform detects henipavirus antivirals

3 June 2021 | By Victoria Rees (Drug Target Review)

A new high-throughput screening platform has been used to identify two compounds with antiviral activity against the Nipah and Hendra viruses.

news

High-throughput screening assay developed to discover antimalarials

21 May 2021 | By Victoria Rees (Drug Target Review)

A new assay has been developed to screen for small molecule inhibitors of the Rh5 protein, which is essential for malaria parasite survival.

Cellular Thermal Shift Assays - bringing relevant target engagement to your drug discovery workflow

webinar

Cellular Thermal Shift Assays – bringing relevant target engagement to your drug discovery workflow

11 May 2021 | By PerkinElmer

Get the Big Picture and listen to Pharma thought leaders how they view CETSA® and its impact on their Drug Discovery.

Antibodies attack virus after antibody discovery development

article

ebook: Antibody Discovery – technology and techniques to boost development

6 May 2021 | By Sartorius

The latest ebook from Sartorius takes an in-depth look at the technologies and techniques that have been integral to developing the antibody discovery workflow, featuring a host of expert articles, interviews and application notes.

news

Lead compound to potentially treat pulmonary arterial hypertension found

6 May 2021 | By Victoria Rees (Drug Target Review)

After screening 4,500 compounds using induced pluripotent stem cells, researchers have identified one lead that could treat pulmonary arterial hypertension.

news

Small-molecule cocktail could improve use of stem cells in treatments

4 May 2021 | By Victoria Rees (Drug Target Review)

Researchers have shown that Chroman 1, Emricasan and trans-ISRIB, in combination with polyamines, are effective at protecting induced pluripotent stem cells from stress.

Realise the true power of your online, atline and offline biologics data

webinar

Realise the true power of your online, atline and offline biologics data

22 April 2021 | By IDBS

Register today for our on-demand upcoming webinar and discover more on about Polar High-Throughput Process Development (HTPD).

news

Fragment screening used to identify potential SARS-CoV-2 antivirals

15 April 2021 | By Victoria Rees (Drug Target Review)

Researchers have used fragment screening alongside computational docking to reveal 20 hit antiviral compounds against SARS-CoV-2.

Hit discovery for GPCRs: HTS or virtual screens?

webinar

Hit discovery for GPCRs: HTS or virtual screens?

8 April 2021 | By Beacon Discovery

Watch our on-demand webinar and learn from an industry expert regarding GPCR virtual screening approaches and challenges and much more.

news

X-ray screening reveals two promising SARS-CoV-2 drug candidates

6 April 2021 | By Victoria Rees (Drug Target Review)

Using a high-brilliance X-ray lightsource and protein crystallography, researchers have identified two drugs that inhibit the main protease of SARS-CoV-2.

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High Throughput Screening (HTS)