news UTX gene mutation “robs” individuals of natural cancer protection 10 November 2021 | By Anna Begley (Drug Target Review) The UTX gene mutation was found to lead to an increased cancer risk, presenting a potential drug target for preventative therapies.
news Novel intestine chip enables effective in vitro study of COVID-19 therapies 10 November 2021 | By Anna Begley (Drug Target Review) The intestine chip was infected with a coronavirus to test a variety of drugs, presenting a new method to investigate COVID-19 treatments.
news Researchers achieve DNA methylation removal in mouse models 9 November 2021 | By Anna Begley (Drug Target Review) The study showed that DNA “de-methylation” activity can be targeted to anywhere in the DNA and may be a new therapeutic strategy.
news MicroRNA in red blood cells causes vascular damage in type 2 diabetes 9 November 2021 | By Anna Begley (Drug Target Review) Researchers discovered that cardiovascular damage was caused by reduced microRNA-210 levels in patient cells and mice with type 2 diabetes.
news ABI3 gene may be the key to new Alzheimer’s disease therapies 8 November 2021 | By Anna Begley (Drug Target Review) The study found that deleting the ABI3 gene in mice increased plaques and inflammation in the brain, suggesting avenues for new treatments.
news Researchers identify RNA molecule that suppresses prostate tumours 8 November 2021 | By Anna Begley (Drug Target Review) Scientists discover a long noncoding RNA, termed NXTAR, and a small molecule drug that could be used to treat prostate cancer.
news Tropical frog models reveal novel kidney disease insights 5 November 2021 | By Anna Begley (Drug Target Review) Scientists utilised CRISPR technology and deep learning systems to investigate the genes associated with polycystic kidney disease.
news Fruit flies could unveil new genetic targets for obesity treatment 5 November 2021 | By Anna Begley (Drug Target Review) Researchers used obese fruit flies to analyse how gene activities affect triacylglyceride levels, unveiling novel drug targets for obesity.
news New class of CAR T cells combat previously “untargetable” cancer drivers 4 November 2021 | By Anna Begley (Drug Target Review) The peptide-centric chimeric antigen receptors killed neuroblastoma cells in mice and could potentially expand the pool of immunotherapeutic targets.
news Gene therapy bolsters Parkinson’s drug benefits in pre-clinical study 3 November 2021 | By Anna Begley (Drug Target Review) The gene therapy restored the ability of neurons to convert levodopa to dopamine and may help develop therapies to slow disease progression.
news Moderna and Metagenomi to develop in vivo gene therapies 3 November 2021 | By Anna Begley (Drug Target Review) Moderna and Metagenomi have announced a collaboration to jointly create next-generation in vivo gene editing therapeutics.
news Scientists eliminate key Alzheimer’s feature in animal model 1 November 2021 | By Anna Begley (Drug Target Review) Turning off NHE6 in mice in pre-clinical studies prevented amyloid beta aggregation, a key feature of Alzheimer's disease, pointing to new therapies.
news Machine learning models predict antibiotic resistance spread 29 October 2021 | By Anna Begley (Drug Target Review) Scientists have used several machine learning models to predict bacterial gene exchange, which could reveal novel antibiotic targets.
news Scientists target ALS and dementia RNA using novel molecule 28 October 2021 | By Anna Begley (Drug Target Review) The small molecule successfully targeted the C9orf72 gene that causes amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD).
news Experimental mouse model reveals potential progeria treatment strategy 27 October 2021 | By Anna Begley (Drug Target Review) Scientists have found that Hutchinson-Gilford Progeria Syndrome (HGPS) can be prevented with treatments targeting the cardiovascular system using a novel mouse model.
