news UTX gene mutation “robs” individuals of natural cancer protection 10 November 2021 | By Anna Begley (Drug Target Review) The UTX gene mutation was found to lead to an increased cancer risk, presenting a potential drug target for preventative therapies.
news Novel intestine chip enables effective in vitro study of COVID-19 therapies 10 November 2021 | By Anna Begley (Drug Target Review) The intestine chip was infected with a coronavirus to test a variety of drugs, presenting a new method to investigate COVID-19 treatments.
news Researchers achieve DNA methylation removal in mouse models 9 November 2021 | By Anna Begley (Drug Target Review) The study showed that DNA “de-methylation” activity can be targeted to anywhere in the DNA and may be a new therapeutic strategy.
news ABI3 gene may be the key to new Alzheimer’s disease therapies 8 November 2021 | By Anna Begley (Drug Target Review) The study found that deleting the ABI3 gene in mice increased plaques and inflammation in the brain, suggesting avenues for new treatments.
news Researchers identify RNA molecule that suppresses prostate tumours 8 November 2021 | By Anna Begley (Drug Target Review) Scientists discover a long noncoding RNA, termed NXTAR, and a small molecule drug that could be used to treat prostate cancer.
news Fruit flies could unveil new genetic targets for obesity treatment 5 November 2021 | By Anna Begley (Drug Target Review) Researchers used obese fruit flies to analyse how gene activities affect triacylglyceride levels, unveiling novel drug targets for obesity.
news New class of CAR T cells combat previously “untargetable” cancer drivers 4 November 2021 | By Anna Begley (Drug Target Review) The peptide-centric chimeric antigen receptors killed neuroblastoma cells in mice and could potentially expand the pool of immunotherapeutic targets.
news Researchers identify COVID-19 proteins that cause blood vessel damage 3 November 2021 | By Anna Begley (Drug Target Review) Scientists revealed five proteins that cause blood vessel damage in COVID-19 patients, potentially leading to new drug targets.
news Scientists eliminate key Alzheimer’s feature in animal model 1 November 2021 | By Anna Begley (Drug Target Review) Turning off NHE6 in mice in pre-clinical studies prevented amyloid beta aggregation, a key feature of Alzheimer's disease, pointing to new therapies.
news Machine learning models predict antibiotic resistance spread 29 October 2021 | By Anna Begley (Drug Target Review) Scientists have used several machine learning models to predict bacterial gene exchange, which could reveal novel antibiotic targets.
news Scientists target ALS and dementia RNA using novel molecule 28 October 2021 | By Anna Begley (Drug Target Review) The small molecule successfully targeted the C9orf72 gene that causes amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD).
news Experimental mouse model reveals potential progeria treatment strategy 27 October 2021 | By Anna Begley (Drug Target Review) Scientists have found that Hutchinson-Gilford Progeria Syndrome (HGPS) can be prevented with treatments targeting the cardiovascular system using a novel mouse model.
news Gene therapy shows promise for Angelman syndrome treatment 26 October 2021 | By Anna Begley (Drug Target Review) A new gene therapy restored motor skill-learning and usual behaviours in Angelman syndrome mouse models, suggesting a novel therapy for the condition.
news Algorithm identifies cancer drugs to treat pulmonary hypertension 21 October 2021 | By Anna Begley (Drug Target Review) Scientists have identified potential cancer drugs to treat pulmonary hypertension using experimental and computational approaches.
news New single-cell and metagenomic technique can characterise microbes 14 October 2021 | By Anna Begley (Drug Target Review) The metagenomic method, termed SMAGLinker, could improve the accuracy and resolution of microbial characterisation to improve medicine design.
