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Green tea compound helps siRNA slip inside cells
Researchers have found a surprising use for EGCG: sneaking therapeutic RNAs into cells...
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Enzymes
Enzymes are macromolecular biological catalysts. Enzymes accelerate, or catalyse, chemical reactions.
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Application note: NanoBRETTM assay for monitoring of ligand binding to GPCRs in live cells, using the CLARIOstar® and the PHERAstar® FS
Due to the crucial role of G protein-coupled receptors (GPCRs) in mediating cellular responses to external stimuli, these receptors have been and will remain a prime focus for medical research and the pharmaceutical industry for many years to come. Their importance is especially highlighted by the statistic that 30-50% of…
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CypA enzyme found in breast milk identified as a target for novel breast cancer drugs
Researchers have identified a protein involved in milk production that could ultimately serve as a target for novel therapies to treat breast cancer...
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Researchers share mass screening method against NSD2 cancer target
Scientists have shared a new method that aims to accelerate the discovery of chemical compounds that inhibit a particular enzyme implicated in several cancers.
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Scientists identify mechanism that links epigenetic change to memory reconsolidation
Researchers in the U.S. have identified a new link between epigenetic changes in the brains of rats and resulting translational control during fear memory reconsolidation.
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Making an early link between cognitive impairment and Alzheimer’s
Researchers in the U.S. have devised a novel strategy to effectively identify those individuals with mild cognitive impairment that will most likely go on to develop Alzheimer's disease.
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Application note: Monitoring receptor ligand binding in living cells
In this application note we will show how a cAMP BRET biosensor can be used to monitor ligand binding with the help of the CLARIOstar microplate reader...
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New targets found to reduce blood vessel damage in diabetes
Researchers identify new treatment targets for diseases associated with endothelial cell senescence, or ageing, such as diabetes, cardiovascular disease and age-related disorders...
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Progress toward improved Wilson’s disease drug
Researchers have conducted promising preclinical experiments on a compound that could be used to treat Wilson's disease...
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Scientists uncover steps to kinase enzyme activation
A new study by the University of Arizona (UA) suggests that revealing all the steps required to activate an enzyme called a protein kinase may help identify new ways to target cancer.
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Cambinol halts spread of toxic protein associated with Alzheimer’s progression
Research could help lead to the design of drugs that slow neurodegeneration...
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Study offers new approach to starve p53 deficient tumours
Sanford Prebys Medical Discovery Institute (SBP) researchers recently discovered an alternative metabolic pathway that might be used by cancer cells to survive nutrient deprivation.
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Targeting telomerase as therapeutic strategy for melanoma
Combination therapy co-targeting the mitochondria enhances the antitumour effect of telomerase inhibition in NRAS-mutant melanoma.
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SAMHD1 enzyme may block HIV disease progression
One way to fight diseases including HIV infection and autoimmune disorders could involve changing how a naturally occurring enzyme called SAMHD1 works...
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SLU scientist turns off chemo pain in the laboratory
Saint Louis University researchers have had success in an animal model in turning off the excruciating pain that often accompanies a colorectal cancer drug.
