news Pathway and enzyme responsible for CKD thrombosis identified 2 November 2021 | By Anna Begley (Drug Target Review) Scientists have discovered a novel pathway and enzyme that causes thrombosis in chronic kidney disease (CKD) patients, indicating a new drug target.
news MIT study reveals how lipid imbalance affects cancer growth in mice 21 October 2021 | By Anna Begley (Drug Target Review) In a new study, a calorie-restricted diet significantly reduced tumour growth in mouse models, suggesting new possibilities for cancer therapies.
news Neurolysin shown to be potential drug target for ischemic stroke 13 October 2021 | By Anna Begley (Drug Target Review) Researchers are identifying molecules that interact with neurolysin, a peptidase that helps protect the brain against stroke.
news Novel class of LPPOs could provide alternative to antibiotics, study shows 30 September 2021 | By Anna Begley (Drug Target Review) Lipophosphonoxins may represent the next generation of antibiotics and can be delivered using a new type of dressing for skin wounds.
news CRISPR-based droplet method speeds up gene therapy research 28 September 2021 | By Anna Begley (Drug Target Review) The new CRISPR-based technology called MIC-Drop rapidly identified several genes for heart development and function in zebrafish.
news Scientists reveal that glioblastoma shows dependency on biotin distribution 15 September 2021 | By Anna Begley (Drug Target Review) Researchers discovered that glioblastoma cells rely on biotin distribution for growth, leading to possible future drug combinations.
news Gene therapy for Morquio A disease successful in rat model 14 September 2021 | By Anna Begley (Drug Target Review) A novel gene therapy has fully corrected whole-body alterations in a rat model, paving the way for Morquio A therapies.
news Immune cells found co-operating to capture and “eat” bacteria 13 September 2021 | By Anna Begley (Drug Target Review) Researchers have identified a spider-like antibacterial mechanism by immune cells that could inspire Staphylococcus aureus treatments.
news PP2A enzyme could be major driver of preeclampsia 10 September 2021 | By Anna Begley (Drug Target Review) A new study found that protein phosphatase 2 (PP2A) found to be a major driver of preeclampsia, potentially leading to treatments.
news Controlling HSP27 “switch” could be key to sepsis therapeutics 1 September 2021 | By Anna Begley (Drug Target Review) Study reveals that the HSP27 protein plays a role in regulating blood vessel leakage, providing new targets for drugs against sepsis.
news New study may improve enzyme replacement therapy for Pompe patients 24 August 2021 | By Anna Begley (Drug Target Review) Researchers have developed a new method that could make enzyme replacement therapy more efficient for Pompe disease treatment.
news Novel database could accelerate drug repurposing for various diseases 4 August 2021 | By Anna Begley (Drug Target Review) NICEdrug.ch is an open-access database that may help scientists assess potential drugs for a range of diseases more quickly.
news Enzyme found to be an “Achilles’ heel” in ovarian cancers 2 August 2021 | By Anna Begley (Drug Target Review) Scientists have uncovered the crucial role of the enzyme NMNAT-2 in ovarian cancers, as well as other biomarkers that could lead to treatments.
news Inhibiting PIP4K enzymes could help immune system fight cancer 27 July 2021 | By Anna Begley (Drug Target Review) Researchers identified a potential therapeutic involving the inhibition of PIP4K enzymes which could enable the immune system to destroy tumour cells.
news Metabolic pathway could potentially enhance vaccine effectiveness 8 July 2021 | By Anna Begley (Drug Target Review) A metabolic control pathway that regulates T follicular helper cells could enhance vaccine effectiveness, including those that protect against COVID-19.
