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Pathway and enzyme responsible for CKD thrombosis identified
Scientists have discovered a novel pathway and enzyme that causes thrombosis in chronic kidney disease (CKD) patients, indicating a new drug target.
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Enzymes
Enzymes are macromolecular biological catalysts. Enzymes accelerate, or catalyse, chemical reactions.
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MIT study reveals how lipid imbalance affects cancer growth in mice
In a new study, a calorie-restricted diet significantly reduced tumour growth in mouse models, suggesting new possibilities for cancer therapies.
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Neurolysin shown to be potential drug target for ischemic stroke
Researchers are identifying molecules that interact with neurolysin, a peptidase that helps protect the brain against stroke.
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Novel class of LPPOs could provide alternative to antibiotics, study shows
Lipophosphonoxins may represent the next generation of antibiotics and can be delivered using a new type of dressing for skin wounds.
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CRISPR-based droplet method speeds up gene therapy research
The new CRISPR-based technology called MIC-Drop rapidly identified several genes for heart development and function in zebrafish.
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Scientists reveal that glioblastoma shows dependency on biotin distribution
Researchers discovered that glioblastoma cells rely on biotin distribution for growth, leading to possible future drug combinations.
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Gene therapy for Morquio A disease successful in rat model
A novel gene therapy has fully corrected whole-body alterations in a rat model, paving the way for Morquio A therapies.
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Immune cells found co-operating to capture and “eat” bacteria
Researchers have identified a spider-like antibacterial mechanism by immune cells that could inspire Staphylococcus aureus treatments.
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PP2A enzyme could be major driver of preeclampsia
A new study found that protein phosphatase 2 (PP2A) found to be a major driver of preeclampsia, potentially leading to treatments.
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Controlling HSP27 “switch” could be key to sepsis therapeutics
Study reveals that the HSP27 protein plays a role in regulating blood vessel leakage, providing new targets for drugs against sepsis.
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New study may improve enzyme replacement therapy for Pompe patients
Researchers have developed a new method that could make enzyme replacement therapy more efficient for Pompe disease treatment.
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Novel database could accelerate drug repurposing for various diseases
NICEdrug.ch is an open-access database that may help scientists assess potential drugs for a range of diseases more quickly.
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Enzyme found to be an “Achilles’ heel” in ovarian cancers
Scientists have uncovered the crucial role of the enzyme NMNAT-2 in ovarian cancers, as well as other biomarkers that could lead to treatments.
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Inhibiting PIP4K enzymes could help immune system fight cancer
Researchers identified a potential therapeutic involving the inhibition of PIP4K enzymes which could enable the immune system to destroy tumour cells.
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Metabolic pathway could potentially enhance vaccine effectiveness
A metabolic control pathway that regulates T follicular helper cells could enhance vaccine effectiveness, including those that protect against COVID-19.
