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Targeting the growth signals of ‘undruggable’ cancers
Dr Bivona and his team showed that the growth of multiple cancers slowed by suppressing the signalling pathway using an experimental compound...
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Drug Targets
A drug target is anything within a living organism to which a drug is directed and/or binds, resulting in a change in its behaviour or function.
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Autoimmune response drives vision loss in glaucoma
New research shows that immune cells developed from early exposure to bacteria contribute to vision loss in glaucoma patients...
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Drugs in development for cancer may also fight brain diseases
PARP inhibitors show promise in preventing toxic accumulations of brain disease proteins in Penn research study...
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‘Drug cocktails’ could strengthen targeted cancer therapies
"Targeted therapies have revolutionised cancer treatment by targeting fewer components within a human cell, thereby promising better efficacy..."
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New drugs targeting gut microbes may reduce the risk of cardiovascular disease
The new class of drugs are mechanism-based inhibitors which potentially interrupt the gut microbial pathway that produces TMAO...
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pH imbalance in astrocytes may lead to Alzheimer’s disease
The researchers found that 10 of the 100 most frequently down-regulated genes were connected with proton flow in the cell...
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miR-132 offers hope for novel Alzheimer’s treatments
The study of neuroprotective microRNAs like miR-132 may lead to new avenues for treating Alzheimer's disease and other tau pathologies...
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Cas12a enzyme could make CRISPR gene-editing more effective
Scientists have identified an easy upgrade for the technology that would lead to more accurate gene editing...
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Potential peptide drug could treat liver cancer effectively
Researchers have discovered that FFW and Sorafenib used together could reduce the growth of Sorafenib resistant hepatocellular carcinoma tumours...
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D-PDMP reverses hair loss and skin damage linked to fatty diet
In a series of experiments, researchers have used an experimental compound to successfully reverse hair loss, hair whitening and skin inflammation...
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Is acidity the weakness of cancer cells?
Cancer cells proliferating in alkalinity should be more vulnerable in acidic environments, so decreasing the pH may result in decreased proliferation...
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AI system designs drugs from scratch
An artificial-intelligence approach created can teach itself to design new drug molecules from scratch and has the potential to dramatically accelerate the design of new drug candidates...
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CBD improves survival rates of mice with pancreatic cancer
Mice with pancreatic cancer that were treated with CBD alongside chemotherapy, survived almost three times longer than those treated with chemotherapy alone...
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CMPK2 inhibitor could lesson symptoms of common illnesses
CMPK2 inhibitors may reduce inflammation, pain and tissue damage in arthritis and gout and in Alzheimer’s may slow loss of cognitive function...
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BCX7353 shows hope for hereditary angioedema
A new drug has been developed to help prevent attacks of hereditary angioedema and at the same offer patients a convenient administration...
