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Defective proteins found to be potential targets for Alzheimer’s treatments
US researchers have identified potential new treatment targets for Alzheimer’s disease, as well as existing drugs that could be used against these targets.
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Drug Targets
A drug target is anything within a living organism to which a drug is directed and/or binds, resulting in a change in its behaviour or function.
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Promising new avenue to tackle obesity-related diabetes
New findings from collaborative research in the United States have identified a promising new treatment avenue for type 2 diabetes patients centring on the activity of the amino acid, GABA.
whitepaper
Catalogue: Drug target reagents
5,000+ drug target reagents for antibody, small molecule drug discovery and development, including immune checkpoints, cytokines and kinases.
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Immunosurveillance and the importance of CD4 T cells in developing cancer vaccines
In this article, Dr Lien Lybaert describes how the innate and adaptive immune system work together to produce an effective and durable antitumour response. She explains why the best strategy for personalised cancer therapy is therefore to identify major histocompatibility (MHC) binding epitopes to cover the full antigenic repertoire of…
podcast
Episode 1 – Dr Sri Gopal, Janssen Pharmaceuticals
Listen along to learn more about drug development for schizophrenia from Dr Sri Gopal, Head of Psychiatry R&D for Janssen!
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New drug shows potential as prophylactic for Alzheimer’s disease
In pre-clinical studies, a novel treatment decreased plaque formation, meaning it could be used to prevent Alzheimer's disease.
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SARS-CoV-2 model shows Spike protein co-operation
A new coarse-grained model of the complete SARS-CoV-2 virion has revealed potential new ways to combat the coronavirus.
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Scientists uncover structural biology details of SARS-CoV-2 infection
Researchers have used computer simulations to model how the SARS-CoV-2 fusion peptide interacts with and penetrates the cell membrane.
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Drugs with potential to stop plaque build-up in arteries identified
A new compound can inhibit the build-up of plaque in arteries and prevent atherosclerosis, researchers have shown.
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Researchers identify new therapeutic targets on SARS-CoV-2 Spike protein
Researchers have found that the S1/S2 cleavage of the SARS-CoV-2 Spike protein could be a potential target for COVID-19 therapeutics.
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Researchers find MAPK4 enzyme presents target for prostate cancer
Research has shown that MAPK4 activates two molecules in cellular signalling pathways involved in prostate cancer growth.
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NOX5: a novel target for sensitising melanoma to therapies
Vito Quaranta, professor of biochemistry and pharmacology, discusses how cancerous cells adopting novel mechanisms of energy production could be sensitised to existing therapies with a focus on melanoma.
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NAD depletion by IFN sensitises pancreatic cancer to NAMPT inhibition, study shows
High IFN signalling in pancreatic tumours are sensitive to NAMPT inhibitors which block a pathway in NAD synthesis, presenting a drug target.
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Targeting Nsp1 protein could be a pathway for COVID-19 therapy
A study has shown that targeting the protein Nsp1 can inhibit genes for viral replication, which could lead to new COVID-19 treatments.
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β-cell regeneration discovery could pave way for diabetes treatments
A key process in β-cell regeneration has been discovered by researchers who say this could lead to improved treatments for diabetes.
