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Drug Leads

cartoon of a pancreas surrounded by various small molecules on a blue abstract background - idea of pancreatic cancer therapies

news

Inhibiting cadherin 11 significantly increases survival of mice with pancreatic cancer

9 December 2020 | By Hannah Balfour (Drug Target Review)

Mice treated with a small molecule inhibitor of cadherin 11 (CDH11) had reduced pancreatic cancer growth and increased survival time.

Bees laying red propolis at the edges of their hive. The propolis resin protects the hive from bacteria and fungus.

news

Red propolis could be a better treatment for schistosomiasis

8 December 2020 | By Hannah Balfour (Drug Target Review)

Investigators found that red propolis can kill schistosomes at all stages of development and therefore suggest it could be highly effective for treating schistosomiasis.

news

Oral drug blocks SARS-CoV-2 transmission in ferrets, researchers find

4 December 2020 | By Victoria Rees (Drug Target Review)

A team has found that their drug Molnupiravir (MK-4482/EIDD-2801) acts as an antiviral against SARS-CoV-2 in pre-clinical studies.

silver T lymphocytes (cells) on a light blue to white gradient background

news

A novel CAR T-cell therapy for type 1 diabetes

4 December 2020 | By Hannah Balfour (Drug Target Review)

Researchers show how genetically engineered five-module chimeric antigen receptor (5MCAR) T cells can be directed to destroy T cells causing autoimmune diseases.

cartoon of blue coronavirus particles surrounding pink human lungs - idea of SARS-CoV-2 lung pathology

news

Researchers provide new insights into SARS-CoV-2 lung pathology

3 December 2020 | By Hannah Balfour (Drug Target Review)

The new study shows how SARS-CoV-2 significantly remodels cellular processes in just an hour and identifies potential drug targets and therapeutics for COVID-19.

white lab mouse sat in a petri dish held in a researcher's gloved hands

news

Novel peptide therapy improves COVID-19 survival by LEAPS and bounds in mice

3 December 2020 | By Hannah Balfour (Drug Target Review)

Researchers report that their LEAPS COV-19 peptides significantly improved survival in a murine model of COVID-19.

article

A rational approach to discover and precision-engineer new biologic drugs

2 December 2020 | By Jerome Boyd-Kirkup (Hummingbird Bioscience)

When it comes to developing antibody drugs, Dr Jerome Boyd-Kirkup and his team are not sticking to the classical playbook. Here, he explains how they use systems biology and immuno-engineering to remove the element of luck from biologic drug discovery and development.

Pink Zika virus particles on an abstract black and purple background

news

Tetracycline antibiotics show promise against Zika virus

25 November 2020 | By Hannah Balfour (Drug Target Review)

A new study shows that methacycline, a commonly used antibiotic, can reduce the neurological damage caused by Zika virus infections in mice.

news

Network modelling reveals a potential new Alzheimer’s therapy

25 November 2020 | By Hannah Balfour (Drug Target Review)

Researchers used integrative network biology analysis to identify the molecular mechanisms that may drive Alzheimer’s and identified a potential therapeutic intervention.

news

Simple molecule could combat antibiotic-resistant gonorrhoea and meningitis, study shows

25 November 2020 | By Victoria Rees (Drug Target Review)

An inexpensive molecule showed efficacy against antibiotic-resistant Neisseria gonorrhoeae and Neisseria meningitidis in an animal model.

news

Drug target and candidate for paediatric heart failure identified

23 November 2020 | By Victoria Rees (Drug Target Review)

A group of researchers has found a drug candidate named TRV027 that can increase the cardiac contractility of neonatal mice.

news

Compound that prevents replication of SARS-CoV-2 identified by researchers

20 November 2020 | By Victoria Rees (Drug Target Review)

Researchers say that the Ebselen compound can inhibit the replication of SARS-CoV-2 in the laboratory, so could combat COVID-19.

news

Researchers identify potential compound to inhibit inflammation

20 November 2020 | By Victoria Rees (Drug Target Review)

Researchers have found a compound that can prevent up-regulation of CD14, a key inflammatory protein, in cells.

cartoon of a syringe with white blobs coming out of it to attack yellow cancerous cells in tissue - idea of a cancer vaccine

article

Developing an effective vaccine for breast cancer

20 November 2020 | By Hannah Balfour (Drug Target Review)

This article summarises the development and testing of a novel vaccine that could be personalised for the treatment of immunotherapy-resistant cancers, such as triple-negative breast cancer (TNBC).

pile of colourful medication tablets with a central white tablet labelled 'hydroxychloroquine'

news

Researchers identify three drugs that could be repurposed for COVID-19

19 November 2020 | By Hannah Balfour (Drug Target Review)

The candidates were screened based on their similarity to hydroxychloroquine and tested for efficacy against SARS-CoV-2 in vitro.

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Drug Leads